The renin angiotensin system in childhood hypertension: selective increase of angiotensin-(1-7) in essential hypertension

The Journal of Pediatrics
A C Simões E SilvaRobson A S Santos

Abstract

We examined the activity of the renin-angiotensin system (RAS) in normotensive and hypertensive children. Hypertensive patients (12 with renovascular hypertension and 15 with essential hypertension) and 32 normotensive subjects were evaluated at a Pediatric Nephrology Center. Blood samples for plasma renin activity (PRA) and angiotensin peptides measurements were obtained once from normotensive subjects and before and after treatment from hypertensive patients. Plasma samples were extracted using Bond-Elut cartridges (Analytichem International, Harbor City, Calif), and peptide concentrations were determined by radioimmunoassay (RIA). PRA, Angiotensin I (Ang I), Angiotensin II (Ang II), and Angiotensin-(1-7) [Ang-(1-7)] levels were significantly higher in renovascular hypertensive patients than in normotensive children (3.3 +/- 1.2 vs 0.40 +/- 0.22 ng Ang I/mL/hour, 81.4 +/- 24.8 vs 26.4 +/- 13.4 pg/mL, 59.3 +/- 17.0 vs 21.4 +/- 8.7 pg/mL, 41.0 +/- 10.5 vs 16.2 +/- 7.9 pg/mL, respectively). The surgical treatment normalized blood pressure, PRA, and angiotensins levels. In contrast with renovascular disease, only Ang-(1-7) levels were significantly increased in essential hypertensive patients compared with normotensive (78.8 +/- ...Continue Reading

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Citations

Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ana Cristina Simões E Silva, Joseph T Flynn
Apr 3, 2010·Journal of Molecular Histology·Augusto B ReisFernando M Reis
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Jan 29, 2020·Heliyon·Daniel Massote MagalhãesAna Cristina Simões E Silva
Apr 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juliana Lacerda de Oliveira CamposAna Cristina Simões E Silva
Aug 28, 2020·Protein and Peptide Letters·Virginia M PereiraAdelina M Reis

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