PMID: 6971846Apr 1, 1981Paper

The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
R CoxJ B Little

Abstract

The repair of potentially lethal damage (PLD) after X-rays was studied in plateau phase cultures of nine normal and five ataxia telangiectasia (AT) strains of human fibroblasts. In the normal strains PLD repair was complete after 6 hours of post-irradiation incubation. There were differences in the form of the survival curves of normal strains after maximum PLD repair but the extent of post-irradiation recovery was similar in all strains. In contrast all AT strains were almost completely deficient in PLD repair even when post-irradiation incubation was extended to 18 or 24 hours. The relevance of the PLD repair-deficiency in cultured AT strains to in vivo radiotherapeutic observations in AT patients is briefly discussed.

Citations

Jun 1, 1996·Molecular Aspects of Medicine·M Hall, R T Johnson
Sep 2, 1998·Trends in Genetics : TIG·P A JeggoA R Lehmann
May 1, 1988·Mutation Research·M F Lavin, A L Schroeder

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