The repair response to osteochondral implant types in a rabbit model

Cell and Tissue Banking
Sally R FrenkelKate G Truncale

Abstract

Current treatments for damaged articular cartilage (i.e., shaving the articular surface, perforation or abrasion of the subchondral bone, and resurfacing with periosteal and perichondrial resurfacing) often produce fibrocartilage, or hyaline-appearing repair that is not sustained over time (Henche 1967, Ligament and Articular Cartilage Injuries. Springer-Verlag, New York, NY, pp. 157-164; Insall 1974, Clin. Orthop. 101: 61-67; Mitchell and Shepard 1976, J. Bone Joint Surg. [Am.] 58: 230-233; O'Driscoll et al. 1986, J. Bone Joint Surg. [Am.] 68: 1017-1035; 1989, Trans. Orthop. Res. Soc. 14: 145; Kim et al. 1991, J. Bone Joint Surg. [Am.] 73: 1301-1315). Autologous chondrocyte transplantation, although promising, requires two surgeries, has site-dependent and patient age limitations, and has unknown long-term donor site morbidity (Brittberg et al. 1994, N Engl. J. Med. 331: 889-895; Minas 2003, Orthopedics 26: 945-947; Peterson et al. 2003, J. Bone Joint Surg. Am. 85-A(Suppl. 2): S17-S24). Osteochondral allografts remain a widely used method of articular resurfacing to delay arthritic progression. The present study compared the histological response to four types of osteochondral implants in a rabbit model: autograft, frozen, fre...Continue Reading

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Citations

Aug 30, 2008·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Daniel K Lee
Jul 24, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gerjon HanninkPieter Buma
Jun 8, 2012·Journal of Tissue Engineering and Regenerative Medicine·Hongjun KangQuanyi Guo
Apr 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Asheesh BediRiley J Williams
Jul 27, 2021·The American Journal of Sports Medicine·Suzanne M TabbaaWilliam D Bugbee

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