PMID: 9164464Mar 1, 1997Paper

The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold

Nature Structural Biology
P FuciniT A Holak

Abstract

The 120,000 M(r) gelation factor and alpha-actinin are among the most abundant F-actin cross-linking proteins in Dictyostelium discoideum. Both molecules are rod-shaped homodimers. Each monomer chain is comprised of an actin-binding domain and a rod domain. The rod domain of the gelation factor consists of six 100-residue repetitive segments with high internal homology. We have now determined the three-dimensional structure of segment 4 of the rod domain of the gelation factor from D. discoideum using NMR spectroscopy. The segment consists of seven beta-sheets arranged in an immunoglobulin-like (Ig) fold. This is completely different from the alpha-actinin rod domain which consists of four spectrin-like alpha-helical segments. The gelation factor is the first example of an Ig-fold found in an actin-binding protein. Two highly homologous actin-binding proteins from human with similar sequences to the gelation factor, filamin and a 280,000 M(r) actin-binding protein (ABP-280), share conserved residues that form the core of the gelation factor repetitive segment structure. Thus, the segment 4 structure should be common to this subfamily of the spectrin superfamily. The structure of segment 4 together with previously published elec...Continue Reading

References

Nov 20, 1991·Journal of Molecular Biology·D S WishartF M Richards
Sep 1, 1990·The Journal of Cell Biology·J B GorlinJ H Hartwig
Apr 1, 1989·International Journal of Biological Macromolecules·M D DavisonJ C Wootton
May 4, 1987·European Journal of Biochemistry·S G HybertsG Wagner
Jan 1, 1988·Cell Motility and the Cytoskeleton·J CondeelisS Ogihara
Feb 1, 1980·The Journal of Cell Biology·O I StendahlT P Stossel
Jan 1, 1993·International Archives of Allergy and Immunology·P Stöger, B Wüthrich
Feb 12, 2008·Current Protocols in Molecular Biology·S Tabor

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Citations

Mar 4, 1998·Current Opinion in Cell Biology·Y A PuiusS C Almo
Oct 7, 2009·Molecular Biology and Evolution·Barry A KesnerNikolay V Dokholyan
Feb 26, 2005·Nucleic Acids Research·Erez Y LevanonEli Eisenberg
Jun 15, 2004·Clinical Dysmorphology·Stephen P Robertson
Apr 3, 2007·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Adeleke Halilu AgudaRobert Charles Robinson
Nov 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hendrik Dietz, Matthias Rief
Dec 7, 2007·The Journal of Cell Biology·Fumihiko NakamuraThomas P Stossel
May 26, 2009·Cell Motility and the Cytoskeleton·Carol A OteySilvia M Goicoechea
Nov 8, 2007·Cell Motility and the Cytoskeleton·William B Holmes, Carole L Moncman
Sep 15, 2004·Journal of Molecular Biology·Grzegorz M PopowiczTad A Holak
Feb 18, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Margriet van KogelenbergStephen P Robertson
Dec 21, 2010·Cell Adhesion & Migration·Fumihiko NakamuraJohn H Hartwig
May 5, 2001·Biochimica Et Biophysica Acta·A van der Flier, A Sonnenberg
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Christopher A WaudbyJohn Christodoulou
Jan 12, 2005·Structure·Regina PudasJari Ylänne
Aug 3, 2011·Biophysical Journal·Adam M R de GraffM F Thorpe
Jun 20, 2006·Trends in Biochemical Sciences·Grzegorz M PopowiczTad A Holak
Oct 21, 2015·Biochemical and Biophysical Research Communications·Heike RothAnnette Müller-Taubenberger
Jul 4, 1998·The Journal of Biological Chemistry·T TakafutaS S Shapiro
Jan 14, 2004·Nature Structural & Molecular Biology·Ingo SchwaigerMatthias Rief
Mar 1, 1997·Nature Structural Biology·C E SchuttU Lindberg
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·T P StosselS S Shapiro
May 22, 2009·Journal of Neuropathology and Experimental Neurology·Sherine ShalabyYukiko K Hayashi
Aug 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Achim LöfJan Lipfert
Jul 3, 1999·The Journal of Biological Chemistry·A E El-Husseini, S R Vincent
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J Hartwig, J Italiano
May 29, 2020·Physical Biology·Manon BeneditoStefano Giordano
Jan 9, 2008·The Journal of Biological Chemistry·Richard D S DixonCarol A Otey
Nov 24, 2006·The Journal of Biological Chemistry·Nandkumar KhaireAngelika A Noegel
Sep 24, 2004·Journal of Cell Science·Monika KnuthAngelika A Noegel

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