The replacement of cholesterol by phytosterols and the increase of total sterol content in model erythrocyte membranes

Chemistry and Physics of Lipids
Katarzyna Hac-Wydro

Abstract

The activity of phytosterols on human organism includes the ability of these compounds to incorporate into membranes. In the consequence the plant sterols are able to increase total sterol concentration in membrane or/and to replace cholesterol molecules. The aim of this work was to compare the influence of both these effects on the properties of model erythrocyte membranes. Moreover, the interactions between the plant sterols (beta-sitosterol and stigmasterol) and saturated-monounsaturated phosphatidylcholine were investigated and the condensing and ordering potency of these phytocompounds on membrane phospholipids were thoroughly analyzed. It was found that the addition of the plant sterols into model membrane modifies the condensation, ordering and interactions in the system. Moreover, the replacement of mammalian sterol by phytosterol more strongly influences the model system than even a 10% increase of total sterol concentration induced by the incorporation of the plant sterol, at constant content of cholesterol. The investigated plant sterols at their lower concentration in the mixed system are of similar effect on its properties. At higher content stigmasterol was found to modify the properties of model membrane more str...Continue Reading

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Citations

Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Katarzyna Hąc-WydroMichał Flasiński
Oct 4, 2013·Journal of Oleo Science·Seiichi SakamotoOsamu Shibata
Jan 28, 2014·Colloids and Surfaces. B, Biointerfaces·Katarzyna Hąc-Wydro, Katarzyna Luty
May 20, 2011·Journal of Colloid and Interface Science·Katarzyna Hąc-WydroPatrycja Dynarowicz-Łątka
Dec 3, 2014·The Journal of Pediatrics·Rgia A OthmanPeter J H Jones

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