The replication fork's five degrees of freedom, their failure and genome rearrangements.

Current Opinion in Cell Biology
Ted WeinertA J Clark

Abstract

Genome rearrangements are important in pathology and evolution. The thesis of this review is that the genome is in peril when replication forks stall, and stalled forks are normally rescued by error-free mechanisms. Failure of error-free mechanisms results in large-scale chromosome changes called gross chromosomal rearrangements, GCRs, by the aficionados. In this review we discuss five error-free mechanisms a replication fork may use to overcome blockage, mechanisms that are still poorly understood. We then speculate on how genome rearrangements may occur when such mechanisms fail. Replication fork recovery failure may be an important feature of the oncogenic process. (Feedback to the authors on topics discussed herein is welcome.).

References

Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·X Bi, L F Liu
Jan 1, 1995·Methods in Enzymology·K L Friedman, B J Brewer
Nov 14, 1998·Cell·M SeigneurB Michel
Jun 22, 1999·Journal of Molecular Biology·M Cordeiro-StoneJ D Griffith
Mar 28, 2002·Cellular and Molecular Life Sciences : CMLS·B Elliott, M Jasin
Jul 12, 2002·The EMBO Journal·Vladimir BidnenkoBénédicte Michel
Jul 27, 2002·Science·Richard D KolodnerKyungjae Myung
Apr 15, 2005·Nature·Vassilis G GorgoulisThanos D Halazonetis
Jun 7, 2005·Genes & Development·Alison J RattrayJeffrey N Strathern
Aug 2, 2005·Molecular and Cellular Biology·Christopher D PutnamRichard D Kolodner
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Ryan C Heller, Kenneth J Marians
Apr 6, 2007·Nature·Catherine E SmithLorraine S Symington
Jan 30, 2008·Nature Reviews. Genetics·Andrés Aguilera, Belén Gómez-González
Mar 8, 2008·Science·Thanos D HalazonetisJiri Bartek
May 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·David T Long, Kenneth N Kreuzer
Jul 3, 2008·Genes & Development·Monica Segurado, John F X Diffley
Sep 23, 2008·Nature·Eleni P Mimitou, Lorraine S Symington
Dec 19, 2008·Nature·Dana BranzeiMarco Foiani

❮ Previous
Next ❯

Citations

Oct 13, 2011·Journal of Medicinal Chemistry·Jianzhang WuGuang Liang
Feb 1, 2011·Journal of Molecular Cell Biology·Xincheng LuGuangbin Luo
Oct 25, 2012·PLoS Genetics·Ismail IraquiSarah A E Lambert
Sep 24, 2015·Biomolecules·Sarah A Sabatinos, Susan L Forsburg
May 5, 2011·FEBS Letters·Dana Branzei
Jul 27, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hisao MasaiDaisuke Kohda
Sep 10, 2014·Nature Structural & Molecular Biology·Michele GiannattasioDana Branzei
May 3, 2011·DNA Repair·Cyril CharbonnelCharles I White

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.