The reproducibility of cytomorphometrical grading of bladder tumours

Virchows Archiv. A, Pathological Anatomy and Histopathology
H G van der PoelA Wijsman-Grootendorst

Abstract

The reproducibility of cytomorphometrical nuclear area measurements on transitional cell carcinoma is studied. The inter-individual consistency is low (r = 0.55, P = 0.0005) when nuclei for measurement are chosen at random. When we use a systematic analysis based on cell situation and cytological features of malignancy to select the 50 nuclei for measurement per slide, the consistency between two technicians appears to be significantly higher (r = 0.90, P = 0.015). Not only interindividual consistency increases using the selection, but the correlation with histological tumour grade also improves significantly for both technicians. The results show that cytomorphometry is a method of grading bladder carcinoma when an accurate selection of nuclei to measure is used. Cytomorphometrical studies should contain a clear description of the way the nuclei for measurement are chosen.

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Citations

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·K DonhuijsenL D Leder
May 1, 1993·Diseases of the Colon and Rectum·G T DeansR Spence
Jan 1, 1991·Scandinavian Journal of Urology and Nephrology·P K LipponenM Sotarauta
Nov 1, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji Sung ShimSeok Ho Kang
Jul 1, 1992·The Journal of Urology·H G van der PoelJ A Schalken

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