PMID: 8471408Mar 1, 1993Paper

The reproducibility of quinine bioavailability

British Journal of Clinical Pharmacology
G PaintaudO Ericsson

Abstract

Plasma concentrations of quinine were measured in six healthy volunteers after a duplicate administration of 15 mg kg-1 of quinine hydrochloride orally and the administration of 15 mg kg-1 of quinine dihydrochloride as an infusion over 6 h. Quinine absorption rate devised by deconvolution was shown to be complete in less than 2 h. The mean (+/- s.d.) fraction available (F) was 0.76 (0.11) after both oral doses and maximum plasma drug concentrations occurred at 1.90 (0.83) h and 2.00 (0.30) h, respectively. The reproducibility of absorption was high, with a within-subject coefficient of variation of less than 10% for Cmax, AUC and F. Thus, quinine absorption is extensive, fast and reproducible in healthy volunteers.

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Citations

Jul 4, 2001·Clinical Pharmacokinetics·P T Giao, P J de Vries
Nov 15, 2011·Journal of Pharmaceutical Sciences·Stefanie StrauchDirk M Barends
Mar 18, 2010·British Journal of Clinical Pharmacology·Julius O SoyinkaJames M Cook
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marc LindenbergJennifer B Dressman
Dec 22, 2011·Thérapie·Marie-Clémence VerdierUNKNOWN pour le groupe Suivi Therapeutique Pharmacologique de la Societe Francaise de Pharmacologie et de Therapeutique
Aug 10, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Andrea HubenyMarkus Grube
Aug 6, 2014·Antimicrobial Agents and Chemotherapy·S M D K Ganga Senarathna, Kevin T Batty
May 14, 2003·European Journal of Clinical Pharmacology·Rajaa A MirghaniLeif Bertilsson
Oct 17, 2018·Pharmaceutical Research·Sindisiwe MvangoMohammed O Balogun
Sep 24, 2020·Journal of the American Society of Nephrology : JASN·Ingrid BerlingUNKNOWN EXTRIP workgroup

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