The reproducibility of time-of-flight PET and conventional PET for the quantification of myocardial blood flow and coronary flow reserve with (13)N-ammonia

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Masaya SudaShin-ichiro Kumita

Abstract

This study aimed to validate the reproducibility of quantitative analysis using time-of-flight (TOF) and conventional PET with (13)N-ammonia ((13)N-NH3). Phantom images were reconstructed with and without TOF, and recovery coefficients (RCs) and the percent contrast of each sphere over the percent background variability were assessed. In the clinical study, 21 subjects underwent dynamic (13)N-NH3 PET scanning under stress and rest conditions. The dynamic acquisition images and intra- and inter-observer reproducibility of myocardial blood flow (MBF) and coronary flow reserve (CFR) were compared between reconstructions (with and without TOF). In the phantom study, RCs and the percent contrast of each sphere over the percent background variability was improved with TOF. In the clinical study, the noise of blood pool and myocardial images with TOF was less than that without TOF. Territorial and global intra- and inter-observer reproducibility of MBF and CFR values was excellent. Although segmental intra- and inter-observer reproducibility was excellent, there were larger variations in apex and the segment near the right ventricle (RV) without TOF. These variations became inconspicuous with TOF. Visual image quality, RCs, and percen...Continue Reading

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Citations

Mar 25, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nagara Tamaki
Jul 10, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken DilsizianMark I Travin
Jul 31, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr J SlomkaGuido Germano
Sep 15, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Oct 13, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Johannes Ermert
Dec 3, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Osamu ManabeKeiichiro Yoshinaga
Mar 21, 2017·Current Treatment Options in Cardiovascular Medicine·Sandeep S HedgireBrian B Ghoshhajra
Nov 2, 2016·Clinical Nuclear Medicine·Frank P DiFilippo, Richard C Brunken
Feb 15, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael AlJaroudi, Fadi G Hage
Nov 3, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Roberto SciagràUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)

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