The requirement for and changing composition of the activating protein-1 transcription factor during differentiation of human leukemia HL60 cells induced by 1,25-dihydroxyvitamin D3.

Cancer Research
Xuening Wang, George P Studzinski

Abstract

The activating protein-1 (AP-1) transcription factor complex is a heterogeneous entity, composed in mammalian cells of dimers chosen from a group of at least eight proteins belonging to three families: jun, fos, and activating transcription factor (ATF). The AP-1 complexes participate in diverse biological processes that include cell proliferation, survival, and differentiation. These seemingly contrasting functions have been attributed to the intensity and duration of the signals provided by AP-1, but the biological consequences of changing composition of the AP-1 complex have not been fully explored. Here, we show that functional AP-1 is required for 1,25-dihydroxyvitamin D3 (1,25D)-induced monocytic differentiation, and that the composition of the AP-1 protein complex that binds TRE, its cognate DNA element, changes as cells differentiate. In HL60 cells in an early stage of differentiation, the principal AP-1 components detected by gel shift analysis include c-jun, ATF-2, fos-B, fra-1, and fra-2. In cells with a more established monocytic phenotype, the demonstrable AP-1 components are c-jun, ATF-2, jun-B, and fos-B. Following the addition of 1 nmol/L of 1,25D, the cellular content of each of these four proteins markedly inc...Continue Reading

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Citations

Aug 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Elzbieta Gocek, George P Studzinski
Aug 5, 2015·Journal of Clinical Medicine·Elzbieta Gocek, George P Studzinski
Feb 20, 2015·Journal of Cellular Biochemistry·George P StudzinskiMichael Danilenko
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Ruifang ZhengGeorge P Studzinski
Sep 1, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Xuening WangGeorge P Studzinski
Jan 31, 2007·Annals of the New York Academy of Sciences·Yanyan Hong, Shiuan Chen
Mar 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Spiros A VlahopoulosVassilis Zoumpourlis

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