PMID: 8606472Feb 21, 1996Paper

The residual cognitive effects of heavy marijuana use in college students

JAMA : the Journal of the American Medical Association
Harrison G Pope, Deborah Yurgelun-Todd

Abstract

To assess whether frequent marijuana use is associated with residual neuropsychological effects. Single-blind comparison of regular users vs infrequent users of marijuana. Two samples of college undergraduates: 65 heavy users, who had smoked marijuana a median of 29 days in the last 30 days (range, 22 to 30 days) and who also displayed cannabinoids in their urine, and 64 light users, who had smoked a median of 1 day in the last 30 days (range, 0 to 9 days) and who displayed no urinary cannabinoids. Subjects arrived at 2 PM on day 1 of their study visit, then remained at our center overnight under supervision. Neuropsychological tests were administered to all subjects starting at 9 AM on day 2. Thus, all subjects were abstinent from marijuana and other drugs for a minimum of 19 hours before testing. Subjects received a battery of standard neuropsychological tests to assess general intellectual functioning, abstraction ability, sustained attention, verbal fluency, and ability to learn and recall new verbal and visuospatial information. Heavy users displayed significantly greater impairment than light users on attention/executive functions, as evidenced particularly by greater perseverations on card sorting and reduced learning of...Continue Reading

Citations

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