The Resistance Mechanisms of Lung Cancer Immunotherapy

Frontiers in Oncology
Fen WangQing Zhou

Abstract

Immunotherapy has revolutionized lung cancer treatment in the past decade. By reactivating the host's immune system, immunotherapy significantly prolongs survival in some advanced lung cancer patients. However, resistance to immunotherapy is frequent, which manifests as a lack of initial response or clinical benefit to therapy (primary resistance) or tumor progression after the initial period of response (acquired resistance). Overcoming immunotherapy resistance is challenging owing to the complex and dynamic interplay among malignant cells and the defense system. This review aims to discuss the mechanisms that drive immunotherapy resistance and the innovative strategies implemented to overcome it in lung cancer.

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Citations

Feb 13, 2021·Diagnostics·Baharia MograbiPaul Hofman
Jul 3, 2021·International Journal of Molecular Sciences·Maya A DymovaVladimir A Richter
Aug 28, 2021·International Journal of Molecular Sciences·Justyna BłachPaweł Krawczyk
Oct 9, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ozge SaatciOzgur Sahin

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Methods Mentioned

BETA
biopsy
PBAF

Clinical Trials Mentioned

NCT03631706
NCT03293784

Software Mentioned

MORPHEUS

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