The resistance of P. acnes--primed interferon gamma-deficient mice to low-dose lipopolysaccharide-induced acute liver injury

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Yoshiaki ShimizuM Wayne Flye

Abstract

Endotoxin has been identified as a principal mediator of sepsis, often with resulting multiple organ failure. Although interferon gamma (IFN-gamma) has a central role in controlling bacterial infection through the activation of macrophages and T lymphocytes, it can also enhance the harmful effects of the inflammatory response. To examine the role of IFN-gamma in lipopolysaccharide (LPS)-induced injury, we administered LPS (20 or 800 microg/mouse) alone or as low-dose LPS (20 microg/mouse) 7 days after heat-killed Propionibacterium acnes (P. acnes) injection into wild-type C57BL/6 (B6) mice or IFN-gamma-deficient (GKO) mice (B6 background). Although low-dose (20 microg) LPS alone had no effect on survival, the administration of 800 microg LPS alone resulted in 100% mortality in both B6 and GKO mice without significant hepatic mononuclear cellular infiltration or differences in elevated plasma tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and IL-12 levels. In contrast, mortality after low-dose (20 microg) LPS challenge in P. acnes-primed B6 mice was 100%, but 0% in GKO mice. In vivo plasma cytokine (IFN-gamma, TNF-alpha, IL-6, and IL-12) levels and in vitro cytokine production by hepatic mononuclear cells were si...Continue Reading

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Citations

May 21, 2005·Virchows Archiv : an International Journal of Pathology·Hideki FujiiKenji Kaneda
Jul 23, 2003·The Journal of Surgical Research·Julie A MargenthalerM Wayne Flye
Feb 11, 2005·Current Opinion in Gastroenterology·Zhiping Li, Anna Mae Diehl
Apr 29, 2006·American Journal of Respiratory Cell and Molecular Biology·Joshua G McCaskillStephen L Tilley
Jul 16, 2010·Journal of Leukocyte Biology·Christopher R RomeroEdward R Sherwood
Oct 2, 2003·Biological & Pharmaceutical Bulletin·Hiroshi KuriharaXin-Sheng Yao
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuhiro NakayamaToshiro Sugiyama
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laszlo RomicsGyongyi Szabo
Sep 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin D EllettKenneth D Chavin
Jan 17, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Julie A MargenthalerM Wayne Flye
Sep 18, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Istvan HritzGyongyi Szabo
May 16, 2006·Gastroenterology·Robert F SchwabeDavid A Brenner
Nov 25, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Weike Tao, Edward R Sherwood
Jul 18, 2018·Acta Pharmacologica Sinica·Xin-Zhi WangZhen-Zhou Jiang
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazumi EbataShigeru Saito

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