PMID: 8969928Nov 1, 1996Paper

The resistance of the Wistar/Furth rat strain to steroid hypertension

Endocrine Research
K KayesS Gallant

Abstract

We have previously reported that the Wistar/Furth (W/Fu) rat strain is resistant to mineralocorticoid hypertension. In the current study, we have examined renal mRNA levels for mineralocorticoid receptor (MR), glucocorticoid receptor (GR), renin and Na+, K(+)-ATPase in response to treatment with mineralocorticoids. Uninephrectomized male Wistar (WI) and W/Fu rats were treated with aldosterone or deoxycorticosterone acetate (DOCA) and were given 1% NaCl to drink. Rats were sacrificed after 1, 3 or 7 days of treatment. Renal MR and ATPase mRNA levels were significantly reduced in aldosterone and DOCA-treated WI rats (e.g. MR was 30% on day 3 and ATPase was 50% of control on day 7 of aldosterone treatment). Unexpectedly, GR mRNA levels paralleled the changes in MR. In W/Fu rats the level of message was either unchanged or only moderately altered by this treatment. In vivo administration of the MR antagonist RU28318 or the GR antagonist RU38486 to WI rats for 4 days reduced renal mRNA levels for both subunits of ATPase. In the W/Fu rat, this treatment resulted in no change in the alpha subunit and an increase in the beta subunit of ATPase. In preliminary studies, we have determined that the W/Fu rat is also resistant to dexamethaso...Continue Reading

References

Oct 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·A MolteniA C Brownie
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·S OkretJ A Gustafsson
Apr 1, 1991·Clinical Science·N J SamaniJ D Swales
Jan 1, 1987·Journal of Steroid Biochemistry·R TakedaM Ikeda
Jan 1, 1987·Molecular Endocrinology·J N VanderbiltK R Yamamoto
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C E BurnhamK R Lynch
Oct 1, 1988·Hypertension·S C MakridesH Gavras
Aug 1, 1987·Hypertension·V Sciotti, S Gallant
Sep 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·H J EsberA E Bogden
Jan 1, 1969·Circulation Research·D J Patel, D L Fry
Mar 1, 1980·Kidney International·F G KnoxJ C Strand
Jul 1, 1993·The American Journal of Physiology·L FerderV Pszenny
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·W LiuD Pearce

❮ Previous
Next ❯

Citations

Dec 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aaron ErdelyChris Baylis
Dec 11, 2002·Kidney International·Michael E UllianWayne R Fitzgibbon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.