PMID: 2888808Jul 1, 1987

The resistance of urinary tract pathogens to chlorhexidine bladder washouts

The Journal of Hospital Infection
D J SticklerJ C Chawla

Abstract

Isolates of Providencia stuartii, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae and Streptococcus faecalis from urinary-tract infections in spinally-injured patients together with Escherichia coli 10418 were challenged with chlorhexidine (200 mg l-1) in a model of a catheterized bladder under conditions which simulate the bladder washout technique. All species survived the antiseptic. Organisms growing on the wall of the bladder model appeared to be particularly resistant and electron microscopy showed that these cells were embedded in a protective glycocalyx. The effect of chlorhexidine bladder washouts on the bacterial flora in the urine of patients was also observed and shown to be minimal and temporary. Examination of urinary sediments from patients revealed the presence of micro-colonies of bacteria embedded in a polysaccharide matrix. We conclude that bladder washouts with chlorhexidine are not likely to eliminate established infections with organisms that occur in patients with indwelling bladder catheters.

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Citations

Nov 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D J SticklerJ Chawla
May 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D J SticklerJ Chawla
Jan 30, 1988·Lancet·A V Pollock
Apr 11, 2001·International Journal of Antimicrobial Agents·S K ChoongH N Whitfield
Mar 29, 2000·Journal of Endourology·S K Choong, H N Whitfield
Apr 1, 1991·British Journal of Urology·K A Getliffe, A B Mulhall
Jun 1, 1994·British Journal of Urology·K A Getliffe
Sep 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L GandertonD Stickler
Jan 1, 1993·Urological Research·D J SticklerC Winters
Dec 13, 2005·Journal of Psychiatric and Mental Health Nursing·M England
Nov 1, 1987·The Journal of Hospital Infection·D J Stickler, J C Chawla
Aug 9, 2007·Journal of Autism and Developmental Disorders·Hsu-Min Chiang, Mark Carter
Sep 25, 2002·British Journal of Community Nursing·A Evans, R Feneley
Feb 6, 2021·The Journal of Hospital Infection·Jane BurnsNicola J Irwin

Related Concepts

Urinary Bladder
Implantable Catheters
Tubulicid
Antibiotic Resistance, Microbial
Electron Microscopy
Spinal Injuries
Foley Catheterization
Urinary Tract Infection
Urine

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European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
D J SticklerJ Chawla
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