The Resistant-Population Cutoff (RCOFF): a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations

Journal of Clinical Microbiology
Giorgia ValsesiaErik C Böttger

Abstract

This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-type Escherichia coli populations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation of in vitro AST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.

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Citations

May 13, 2015·Enfermedades infecciosas y microbiología clínica·Andrés Canut-BlascoLuis Martínez-Martínez
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Michael HombachErik C Böttger
Sep 15, 2017·Foodborne Pathogens and Disease·Lohendy Muñoz-VargasGreg Habing
Aug 7, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Regina SelbKlaus Jansen

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