PMID: 41616Dec 28, 1979

The resolution of dopamine and beta 1- and beta 2-adrenergic-sensitive adenylate cyclase activities in homogenates of cat cerebellum, hippocampus and cerebral cortex

Brain Research
A DolphinJ Bockaert

Abstract

The stimulation of adenylate cyclase by dopamine and various beta-adrenergic agonists has been investigated in homogenates from 3 areas of cat brain: the cerebral cortex, cerebellum and hippocampus. The purpose of the study was to determine whether the beta-arenergic receptors coupled to adenylate cyclase could be classified as either beta 1 and beta 2 subtypes in the different regions studied. The stimulation of adenylate cyclase by the beta-adrenergic agonist, (-)isoproterenol (5 X 10(-6) M), was completely blocked by the specific beta-adrenergic antagonist, (p)alprenolol (1-(-5) M), but not by the dopaminergic antagonist, fluphenazine (10(-5) M), whereas the stimulation of adenylate cyclase by (-)epinephrine (10(-4) M) was blocked to varying extents by these two drugs in each of the 3 regions studied. The (-)epinephrine effect was always blocked in the combined presence of (p)alprenolol and fluphenazine. The adenylate cyclase stimulation by (p)epinephrine which is not blocked by (p)alprenolol was due to interaction of (p)epinephrine with a dopaminergic-sensitive adenylate cyclase which has been characterized in cerebral cortex, hippocampus and cerebellum. Regional differences in the affinity of beta-adrenergic-sensitive aden...Continue Reading

References

Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H StrittmatterG Hertting
Jan 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·V HomburgerJ Bockaert
Mar 6, 1992·Brain Research·L E Chavez-Noriega, C F Stevens
Dec 5, 1980·European Journal of Pharmacology·S BischoffJ Krauss
Apr 23, 1985·European Journal of Pharmacology·B Scatton, A Dubois
Aug 9, 1988·European Journal of Pharmacology·J C Fowler, J M O'Donnell
May 1, 1987·Brain Research·R D Oades, G M Halliday
Sep 18, 1981·Biochimica Et Biophysica Acta·I Novak-Hofer, A Malnoë
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F H MaK Kuriyama
May 16, 2009·Neuroscience Letters·Alec PaschalisGareth Ackland
Jan 1, 1987·Molecular Neurobiology·P Greengard
Jan 1, 1990·Journal of Neural Transmission. General Section·M CampsJ M Palacios

Related Concepts

Lung
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Adrenergic beta-Agonists
Adrenergic beta-Agonists [MoA]
Lyogen
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Medihaler-Epi

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