PMID: 14190458Apr 1, 1964Paper

THE RESPIRATORY ACTION OF DICHLORPHENAMIDE

British Journal of Pharmacology and Chemotherapy
D DOYLEK B SLAWSON

Abstract

The action of dichlorphenamide has been investigated in three healthy subjects. After this drug had been given, ventilation increased while alveolar and oxygenated mixed venous Pco(2) both fell. The magnitude of these changes was closely related to the degree of acidosis produced by the drug. The effect of intravenous acetazolamide, tested in one subject, was qualitatively similar to that of orally administered dichlorphenamide. Respiratory responses to carbon dioxide were studied in two of the subjects and in one of them the metabolic acidosis was sufficient to account for the short-term effect of dichlorphenamide on respiration.

References

Jul 1, 1957·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·D J CUNNINGHAMB B LLOYD
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·O S ANDERSENP ASTRUP
Apr 29, 1961·Lancet·M W MCNICOL, N B PRIDE
Nov 1, 1961·Journal of Applied Physiology·S M CAIN, A B OTIS
Oct 1, 1961·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·D J CUNNINGHAMB B LLOYD
Jan 1, 1962·Journal of Applied Physiology·J H STROMME, J FOG
Jan 1, 1963·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J L ANDERTON, E A HARRIS
Mar 1, 1960·The American Journal of Medicine·A NaimarkR M Cherniack
Aug 3, 1921·The Journal of Physiology·J B Haldane

Related Concepts

Acetazolamide Sodium, (Sterile)
Metabolic Acidosis
Blood Gas Analysis
Carbon Dioxide
Carbonic Anhydrase Inhibitors
Glauconide
Pharmacology
Respiration
Respiratory Failure
Toxinology

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