The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model

Biomaterials
A BigiR Giardino

Abstract

An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6Al4V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit cortical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr+HA: 37%; Ti6Al4V+HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb11Zr in comparison with that of HA-coated Ti6Al4V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti-Nb-Zr alloy with the HA coating on bone remodeling and maturation.

References

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Citations

Mar 29, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Jae Hyup LeeChoon-Ki Lee
Sep 13, 2011·Journal of Materials Science. Materials in Medicine·Ji-Hoon JoYoung-Hag Koh
Aug 27, 2009·Tissue Engineering. Part a·Xiaojian WangCui'e Wen
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Jan 1, 2012·Journal of Functional Biomaterials·Bedilu A AlloAmin S Rizkalla
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Jun 15, 2018·International Journal of Implant Dentistry·Dawlat Mostafa, Moustafa Aboushelib
Jun 3, 2017·Journal of Applied Biomaterials & Functional Materials·Adriana Bigi, Elisa Boanini
Jan 17, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Daniel O CostaAmin S Rizkalla

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