The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent.

Molecular and Cellular Biology
K R LaderouteR S Johnson

Abstract

Hypoxia (low-oxygen tension) is an important physiological stress that influences responses to a wide range of pathologies, including stroke, infarction, and tumorigenesis. Prolonged or chronic hypoxia stimulates expression of the stress-inducible transcription factor gene c-jun and transient activation of protein kinase and phosphatase activities that regulate c-Jun/AP-1 activity. Here we describe evidence obtained by using wild-type and HIF-1 alpha nullizygous mouse embryonic fibroblasts (mEFs) that the induction of c-jun mRNA expression and c-Jun phosphorylation by prolonged hypoxia are completely dependent on the presence of the oxygen-regulated transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha). In contrast, transient hypoxia induced c-jun expression in both types of mEFs, showing that the early or rapid induction of this gene is independent of HIF-1 alpha. These findings indicate that the c-jun gene has a biphasic response to hypoxia consisting of inductions that depend on the degree or duration of exposure. To more completely define the relationship between prolonged hypoxia and c-Jun phosphorylation, we used mEFs from mice containing inactivating mutations of critical phosphorylation sites in the c-Jun ...Continue Reading

References

Dec 16, 1992·Biochimica Et Biophysica Acta·S E PlyteJ R Woodgett
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Ryder, D Nathans
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Oct 6, 1995·The Journal of Biological Chemistry·M L Norris, D E Millhorn
Aug 1, 1994·Molecular and Cellular Biology·W A AussererR M Sutherland
Aug 1, 1996·Molecular and Cellular Biology·R JohnsonR Wisdom
Dec 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·H J Rahmsdorf
Apr 1, 1997·Current Opinion in Cell Biology·M KarinE Zandi
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·P H MaxwellP J Ratcliffe
Sep 12, 1997·The Journal of Biological Chemistry·J M MüllerR A Rupec
Dec 12, 1997·Biochimica Et Biophysica Acta·A Minden, M Karin
Feb 3, 1998·Molecular and Cellular Biology·N ClarkeR Prywes
Jul 31, 1998·Frontiers in Bioscience : a Journal and Virtual Library·R St-Arnaud, I Quelo
May 18, 1999·The Journal of Biological Chemistry·S F YanD M Stern
Jun 22, 1999·Nucleic Acids Research·O I OrnatskyJ C McDermott
Aug 7, 1999·The Journal of Biological Chemistry·P W ConradD Beitner-Johnson
Aug 12, 1999·Methods in Molecular Biology·A K HadjantonakisA Nagy
Nov 24, 1999·The Journal of Biological Chemistry·P W ConradD E Millhorn
Dec 2, 1999·Experimental Cell Research·R Wisdom
Feb 5, 2000·Advances in Experimental Medicine and Biology·P Vaupel, M Hoeckel
May 2, 2000·The Journal of Biological Chemistry·S MullerA Dejean

❮ Previous
Next ❯

Citations

Feb 22, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antonio SicaLuigi Varesio
Oct 9, 2003·Breast Cancer Research and Treatment·Ladislav TomesPeter H Watson
Jun 14, 2008·Cell Death and Differentiation·I PapandreouN C Denko
Jul 25, 2008·The Journal of Biological Chemistry·Ling WangLuo Lu
Feb 11, 2009·The Journal of Biological Chemistry·Sarvjeet SinghPradeep P A Mammen
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Thomas Hellwig-BürgelWolfgang Jelkmann
May 4, 2004·Molecular and Cellular Biology·Keith R LaderouteRandall S Johnson
Apr 4, 2013·The Journal of Clinical Investigation·Barbara OnnisGiovanni Melillo
Apr 11, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Grace Vangeison, David A Rempe
Mar 31, 2011·Blood·Johannes SchödelDavid R Mole
Feb 22, 2005·Redox Report : Communications in Free Radical Research·Kazuhiro KatadaToshikazu Yoshikawa
Dec 17, 2014·Environmental Science & Technology·Richard Man Kit YuRichard Yuen Chong Kong
May 13, 2003·Molecular Cancer·Manfred Kunz, Saleh M Ibrahim
Dec 18, 2004·Mutation Research·Ioanna PapandreouNicholas Denko
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongan ZhouLili Liu
Aug 27, 2003·The Journal of Biological Chemistry·Manfred KunzSaleh M Ibrahim
Jan 27, 2007·The EMBO Journal·Dirk SchmidtMarina Schorpp-Kistner
Mar 8, 2007·Annals of the New York Academy of Sciences·Björn TextorMarina Schorpp-Kistner
Jun 16, 2005·International Journal of Cancer. Journal International Du Cancer·Denis MottetCarine Michiels
Jan 9, 2013·Virchows Archiv : an International Journal of Pathology·Petr SteinerOndrej Hes
Mar 31, 2015·The Cancer Journal·Valéry L PayenPierre Sonveaux
Dec 14, 2004·The Oncologist·Peter Vaupel
Jun 18, 2003·The Journal of Biological Chemistry·Tsunenori KodamaHirotoshi Tanaka
May 25, 2004·Journal of Cellular Biochemistry·Olga AprelikovaJ Carl Barrett
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Carla BoscoLuigi Varesio
Apr 24, 2020·Frontiers in Oncology·Shing Yau TamHelen K W Law
Oct 20, 2005·Human Reproduction Update·J L JamesL W Chamley
Jun 10, 2016·The Journal of Biological Chemistry·Ling WangLuo Lu
Jul 10, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhuqing LiWenge Zhu
Jul 25, 2019·Biochemical and Biophysical Research Communications·Shing Yau TamHelen K W Law
Mar 6, 2004·Archives of Biochemistry and Biophysics·Ryoichi YamajiYoshihisa Nakano
Sep 8, 2005·Seminars in Cell & Developmental Biology·Keith R Laderoute

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved