The response of circulating parameters of bone mineral metabolism to ethanol- and EDTA-induced hypocalcemia in the rat

Bone and Mineral
S ThomasF Ismail

Abstract

The mechanism of the acute hypocalcemia that follows acute ethanol administration has not been established. Measurements of parathyroid hormone (PTH) performed during this hypocalcemia reveal conflicting results. We compared the response of ionized calcium (Ca2+), immunoreactive PTH and bone Gla protein (BGP) after ethanol- and EDTA-induced hypocalcemia. 103 male Sprague Dawley rats each weighing approximately 300 g received ethanol and 100 rats of similar weight received EDTA. In each of these studies the animals were divided into experimental and control groups. The ethanol-treated rats received ethanol, 2 g/kg body weight, by ip injection and the EDTA-treated rats received 100 mg EDTA/kg body weight by im injection. Controls received normal saline by the corresponding route of administration. Rats were sacrificed at 0, 30, 60, 90, 180 and 360 min for the measurement of the above parameters. In both experimental groups Ca2+ levels were significantly reduced to the same degree by 30 min with return to control values by 360 min. There was no significant difference in immunoreactive PTH, and BGP between control and ethanol-treated groups. In the EDTA-treated rats, however, PTH values were significantly increased at 30 (P less th...Continue Reading

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Citations

Feb 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T C PengR P Kusy
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·H W SampsonB DeFee
May 1, 1997·Alcoholism, Clinical and Experimental Research·H W Sampson
Jan 28, 2004·Alcoholism, Clinical and Experimental Research·Kathy Keiver
Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Shalu DuggalKathy Keiver
Nov 15, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A LiesegangM Wanner
Apr 1, 1993·British Journal of Industrial Medicine·D DeschampsS Dally
Mar 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H M Frost
May 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N Agarwala, C V Gay
Apr 10, 2009·American Journal of Physiology. Renal Physiology·Eva ParisiJose M Valdivielso
Feb 18, 2003·Journal of Toxicology and Environmental Health. Part a·Shih-Houng YoungVincent Castranova
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P Patterson-BuckendahlR Kvetnanský

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