PMID: 7335104Dec 1, 1981Paper

The response of germ cells of the mouse to the induction of non-disjunction by X-rays

Mutation Research
R M Speed, A C Chandley

Abstract

The sensitivity of male and female pre-meiotic germ cells of the mouse to the induction of non-disjunction by low doses of X-rays, has been tested. No enhancement with 5 rad was observed over control values in dictyate oocytes irradiated from young or aged females. In males, a 3-fold increase in overall chromosome abnormalities (aneuploids, polyploids and mosaics) was found following the treatment of germ cells sampled in the 7th week after irradiation (spermatogonia and early primary spermatocytes) with 100 rad. The increase in aneuploidy alone was not however significant at the 5% level of probability. Primary spermatocytes sampled in week 5 after irradiation were generally insensitive to the induction of chromosome abnormalities.

References

Aug 1, 1979·Environmental Health Perspectives·A C Chandley, R M Speed
Jul 19, 1979·Nature·I HansmannJ Jenderny
Jan 1, 1975·Cytogenetics and Cell Genetics·A GroppD Giers
Nov 1, 1972·Annals of Human Genetics·E AlbermanE Armstrong
Aug 15, 1973·Nature: New Biology·M YamamotoG Watanabe
Aug 16, 1974·Nature·I A Uchida, C P Lee
Feb 17, 1962·Nature·A J BATEMAN, A C CHANDLEY

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Citations

Apr 1, 1983·Mutation Research·I HansmannH D Probeck
Apr 1, 1984·Mutation Research·B M CattanachM Kirk
Dec 1, 1994·Mutation Research·R JohannissonB Brandenburg
Nov 25, 2003·Journal of Applied Microbiology·I ZorrillaJ J Borrego
Jan 1, 1990·American Journal of Medical Genetics. Supplement·P StriginiF Dagna Bricarelli

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