PMID: 9178629Jul 1, 1997Paper

The response of heat shock proteins 25 and 72 to ischaemia in different kidney zones

Pflügers Archiv : European journal of physiology
A SchoberF Beck

Abstract

Induction of heat shock proteins (HSPs) following cell injury contributes to the protection of vital cell functions. It was, therefore, of interest to study the effects of transient renal ischaemia on the abundance and distribution of two HSPs, HSP25 and HSP72, in renal tissue using Western-blot techniques. Analyses were performed on the supernatant (HSP25, HSP72) and pellet (HSP25) of homogenates obtained from cortex (CX) and outer (OM) and inner (IM) medulla of the rat kidney immediately after 60 min of ischaemia followed by varying periods of reperfusion. Ischaemia of the left kidney caused HSP25 contents to decrease in CX, OM and IM by 73, 89 and 54% respectively, compared with the corresponding zones of the contralateral control kidney. This initial decrease in supernatant HSP25 was accompanied by an increased abundance of HSP25 in the pellet. Following reperfusion, HSP25 contents in the supernatant gradually increased in CX and OM, reaching, after 24 h, values that were 5.4- and 2.5-fold higher, respectively, than those in the control kidneys. After 7 or 14 days of reperfusion, HSP25 contents had not completely normalised in CX, but had reached control levels in OM. In IM, the HSP25 content remained below control througho...Continue Reading

Citations

Mar 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christoph Aufricht
Mar 31, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sara M MolinasLaura Trumper
Dec 3, 2009·Cell Stress & Chaperones·Tal MizrahiZeev Arad
Nov 14, 2002·Biochemical Pharmacology·Joanna Jakubowicz-GilAntoni Gawron
Dec 15, 2000·Kidney International·B BidmonC Aufricht
Oct 10, 2002·Kidney International·Bettina BidmonChristoph Aufricht
Oct 22, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Juan Antonio Ortega-TrejoNorma A Bobadilla
May 9, 2014·Kidney International·Rajasree SreedharanScott K Van Why
Apr 14, 2005·Biochemical Pharmacology·J Jakubowicz-GilM Kandefer-Szerszeń
Jul 14, 2016·Physiological Reports·Marie Louise V KristensenRikke Nørregaard
Nov 10, 2017·Canadian Journal of Physiology and Pharmacology·Marco A BrovedanLaura Trumper
Jun 24, 2005·Transplantation·Arjang DjamaliBryan Becker
Jun 20, 2008·American Journal of Physiology. Renal Physiology·Ewen M HarrisonStephen J Wigmore
Feb 13, 2007·Current Opinion in Nephrology and Hypertension·Christopher Y LuJianlin Chen
Jun 22, 2007·American Journal of Physiology. Renal Physiology·Midhun C KorrapatiHarihara M Mehendale
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·S K Van Why, N J Siegel
Aug 5, 2000·American Journal of Physiology. Renal Physiology·F X BeckE Müller
Aug 13, 1999·The American Journal of Physiology·S K van WhyN J Siegel
Apr 15, 2017·Cell Stress & Chaperones·Natalia ChebotarevaEvgeniy Shilov
Apr 17, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patricia VallésDaniel R Ciocca
May 25, 2020·Cell Stress & Chaperones·Patricia G VallésValeria Cacciamani
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Oliver EickelbergNorman Siegel
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Scott K Van WhyNorman J Siegel
Feb 9, 2000·Journal of the American Society of Nephrology : JASN·William E SmoyerRainer Benndorf
Sep 15, 1998·Kidney International. Supplement·A SchoberF X Beck

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