PMID: 6971845Apr 1, 1981Paper

The response of mouse intestine to combined hyperthermia and radiation: the contribution of direct thermal damage in assessment of the thermal enhancement ratio

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
S P Hume, J C Marigold

Abstract

The thermal enhancement of X-ray damage to mouse jejunum has been assessed when heating was achieved by immersion of an exteriorized loop of intestine in Krebs-Ringer solution. The results have been compared with those previously obtained following heating in situ. The primary effect of 1 hour of mild hyperthermia was to reduce the should of the crypt survival curve obtained following X-rays given alone. Thermal enhancement ratio (TER) values increased with increasing temperature, up to 42.3 degrees C, and were within the range reported for other normal tissues. However, when hyperthermia itself caused crypt loss and the contribution of hyperthermal killing to the overall tissue response was taken into account, there was little enhancement of radiation damage. There was no evidence of a large increase in TER at high temperatures, as is seen in some tumours and has been reported by Merino, Peters, Mason and Withers (1978) for intestine. It is possible that very high TER values which have previously been reported mainly reflect the heat-alone component of damage. Some of the implications of these results are discussed in relation to the combination of heat and radiation in therapy.

References

May 1, 1977·Radiology·W C DeweyL E Gerweck
Mar 1, 1979·The British Journal of Radiology·S A Hill, J Denekamp
Aug 1, 1979·The British Journal of Radiology·S P HumeS B Field
Feb 1, 1978·The British Journal of Radiology·M P LawS B Field
Apr 1, 1978·The British Journal of Radiology·F A Stewart, J Denekamp
May 1, 1978·International Journal of Radiation Oncology, Biology, Physics·O R MerinoH R Withers
Feb 1, 1977·The British Journal of Radiology·S B FieldR Myers
Aug 1, 1977·The British Journal of Radiology·C C MorrisS B Field
Oct 1, 1974·Radiology·J E RobinsonW A McCready

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Citations

Jan 1, 1986·The British Journal of Radiology·S P Hume, J C Marigold
Jun 1, 1982·The British Journal of Radiology·S P Hume, J C Marigold
Jul 16, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R WiggenraadJ van der Zee
Jul 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J W PeckL A Dethlefsen
Sep 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J Wondergem, J Haveman
Mar 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S P HumeD G Hirst
Aug 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Wondergem, J Haveman
Feb 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S P Hume, J C Marigold

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