The response of MSTd neurons to perturbations in target motion during ongoing smooth-pursuit eye movements.

Journal of Neurophysiology
Seiji OnoMichael J Mustari

Abstract

Several regions of the brain are involved in smooth-pursuit eye movement (SPEM) control, including the cortical areas MST (medial superior temporal) and FEF (frontal eye field). It has been shown that the eye-movement responses to a brief perturbation of the visual target during ongoing pursuit increases with higher pursuit velocities. To further investigate the underlying neuronal mechanism of this nonlinear dynamic gain control and the contributions of different cortical areas to it, we recorded from MSTd (dorsal division of the MST area) neurons in behaving monkeys (Macaca mulatta) during step-ramp SPEM (5-20 degrees /s) with and without superimposed target perturbation (one cycle, 5 Hz, +/-10 degrees /s). Smooth-pursuit-related MSTd neurons started to increase their activity on average 127 ms after eye-movement onset. Target perturbation consistently led to larger eye-movement responses and decreasing latencies with increasing ramp velocities, as predicted by dynamic gain control. For 36% of the smooth-pursuit-related MSTd neurons the eye-movement perturbation was accompanied by detectable changes in neuronal activity with a latency of 102 ms, with respect to the eye-movement response. The remaining smooth-pursuit-related M...Continue Reading

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Citations

Jul 20, 2011·Cerebral Cortex·Seiji Ono, Michael J Mustari
Sep 3, 2010·The Cerebellum·Jan VoogdChris I De Zeeuw
Jun 24, 2014·Archivos de la Sociedad Española de Oftalmología·J G FrancoE Vilella
Feb 22, 2014·Cerebral Cortex·Lukas BrostekStefan Glasauer
Oct 8, 2016·Journal of Motor Behavior·Seiji Ono, Tomohiro Kizuka
Feb 17, 2017·Journal of Neurophysiology·Leah BakstMichael J Mustari

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