The response of rat adrenal medulla to oxytocin.

Archives internationales de physiologie et de biochimie
B PlećasD Jovović

Abstract

Effects of oxytocin (OT) on the adrenal chromaffin tissue of male rats were examined by coupled morphometric and biochemical techniques. Synthetic OT was administered in doses of 0.14 and 0.25 IU/100 g/d during 7 or 10 consecutive days and the effects were followed 1, 24, 72 and 168 hours after the last injection. The function and structure of chromaffin cells were affected by the higher dose of OT only. They caused divergent responses on their amine contents. Adrenaline, noradrenaline and dopamine contents were increased, while serotonin content was decreased. These changes were different in duration and time of incidence. Stereological analysis showed an enhanced number of chromaffin cells and an increase in their total volume. The parallelism between the changes in chromaffin cell number and the catecholamine content strongly suggests a mitogenic effect of the applied OT.

References

Jan 1, 1977·The Journal of Endocrinology·N H HuntP A Sandford
Sep 1, 1985·Neuroendocrinology·M A Holzwarth, M S Brownfield
Oct 1, 1987·The Journal of Endocrinology·S S NusseyJ S Jenkins
May 2, 1985·Nature·M R Hanley
May 15, 1968·Experientia·G MalvaldiM P Viola-Magni
Jan 1, 1984·Journal of Steroid Biochemistry·N PayetJ G Lehoux
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·V T Ang, J S Jenkins

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Citations

Nov 8, 2002·European Journal of Pharmacology·Cécile LoichotMariette Barthelmebs
Jun 12, 2010·Stress : the International Journal on the Biology of Stress·M OndrejcakovaD Jezova

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