PMID: 9170000May 1, 1997Paper

The response of renal plasma flow to angiotensin II infusion in a population-based sample and its association with the parental history of essential hypertension

Journal of Hypertension
S L KardiaS T Turner

Abstract

Results from previous studies suggested that a blunted response of renal plasma flow (RPF) to angiotensin II infusion during a high-sodium diet (a phenotype associated with nonmodulation) is an intermediate phenotype for essential hypertension. To determine whether RPF traits used to investigate nonmodulation have the characteristics of intermediate traits when examined in a population-based sample of adults aged 20-49.9 years. We examined the frequency distribution of baseline RPF and of its response to All infusion using maximum-likelihood commingling analysis in order to investigate the null hypothesis that the distributions of these traits are unimodal. We also examined the null hypothesis that there is no association between these candidate intermediate traits and the parental history of essential hypertension. There was some evidence for the commingling of multiple distributions underlying these traits both for women and for men but the commingled distributions overlapped substantially and the inferences about the commingling of distributions were sensitive to the method of RPF measurement, exclusion of outliers, and the method of adjustment for concomitants. There was no statistically significant association between any ...Continue Reading

References

Dec 1, 1992·Hypertension·G H WilliamsN K Hollenberg
Aug 1, 1991·Hypertension·S T Turner, V V Michels
Sep 27, 1985·The American Journal of Medicine·G H Williams, N K Hollenberg
Jul 17, 1969·The New England Journal of Medicine·A R ChristliebG H Williams
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Dec 1, 1928·The Journal of Clinical Investigation·J F McIntoshD D Van Slyke

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Citations

Dec 26, 2001·Hypertension·K F HilgersR E Schmieder
Oct 9, 2004·Blood Pressure Monitoring·Sharon L R KardiaJason H Moore
Nov 15, 2000·American Journal of Hypertension·G L SchwartzC F Sing
Jun 21, 2002·American Journal of Hypertension·Stephen T TurnerPatricia A Peyser

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