The response of the newborn rat to injury. I. Vascular and humoral aspects

The Journal of Pathology
C J Dunn, D A Willoughby

Abstract

The development of oedema in response to irritants injected into the skin, or pleural cavity of rats, has been shown to differ according to the age of rat studied. It was found that newborn rats were less responsive, with respect to oedema formation, at certain times after the injection of a particular irritant. Attempts to suppress the reactions of these animals using anti-histamines, anti-serotonin and kinin-depleting agents were less successful than in adults. Analysis of serum, plasma and exudate proteins revealed quantitative and qualitative differences between newborn and adult rats. The ability of various agents to cause increased vascular permeability in the skin of newborn rats was found to vary with the age of animal studied. Thus histamine, 5-hydroxytryptomine, cellulose sulphate and prostaglandin E2, all failed to cause increased vascular permeability in the skin of rats younger than 3 wk of age. However, lymph-node permeability factor induced increased vascular permeability in newborn (i.e., 6-hr-old) rats. An attempt was made to correlate these results with those of oedema formation following the infections of certain irritants.

References

Jul 1, 1970·The Journal of Pathology·J P Giroud, D A Willoughby
Nov 15, 1967·Experientia·I A OyvinV I Oyvin
Nov 1, 1960·The Journal of Physiology·P M TAYLOR
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Nov 1, 1963·The Journal of Experimental Medicine·O D RATNOFF, I H LEPOW
Jan 1, 1951·The Journal of Pathology and Bacteriology·W G SPECTOR

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Citations

Jan 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·N A Klimenko, G Iu Pyshnov
Feb 1, 1976·Agents and Actions·C J Dunn
Oct 1, 1975·Agents and Actions·C J Dunn, D A Willoughby
Dec 13, 2003·Journal of Pharmacological and Toxicological Methods·Felicity N E Gavins, Bristi E Chatterjee
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·F GriscelliP Yeh
Nov 2, 2005·Inflammopharmacology·K D Rainsford
Nov 28, 2001·The European Journal of Neuroscience·P G GreenJ D Levine

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