PMID: 9192503Jul 1, 1997Paper

The response to calcitriol therapy in postmenopausal osteoporotic women is a function of initial calcium absorptive status

Calcified Tissue International
A G NeedB E Nordin

Abstract

Calcitriol is used in the treatment of osteoporosis but the indications for its use have not been clearly defined. Because it stimulates calcium absorption, we have tended to select osteoporotic patients with low calcium absorption for this therapy and now report the results. We measured the hourly fractional rate of calcium absorption (alpha) with 45Ca and fasting urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OHPr/Cr) in 103 postmenopausal women aged 68 (0.67SE) years with vertebral compression fractures (77) or forearm or vertebral bone density below the young normal range (26). They were given 0.25 microg daily of calcitriol (Rocaltrol, Roche, Basle, Switzerland) with a 1 g calcium supplement daily for 6-12 weeks, when the biochemical tests were repeated. Initial OHPr/Cr was inversely related to initial alpha (P = 0.001) and positively to initial Ca/Cr (P < 0.001). alpha rose on therapy from 0.47 (0.018) to 0.59 (0.018) per hour (P < 0. 001) and OHPr/Cr fell in the whole group from 19.1 (0.83) to 13.8 (0. 58) (P < 0.001). The change in alpha on therapy (corrected for the "regression to the mean effect") was inversely related to initial alpha (P < 0.001) as was the change in OHPr/Cr (P = 0.001). There was ...Continue Reading

Citations

Nov 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B E Christopher NordinHoward A Morris
Feb 24, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A PlumH F DeLuca
Jun 3, 2009·Calcified Tissue International·B E Christopher NordinAllan G Need
Mar 15, 2012·Clinical Biochemistry·Paul H AndersonHoward A Morris
Jun 24, 2004·Clinical Endocrinology·B E Christopher NordinMichael Horowitz
Apr 5, 2001·Rheumatic Diseases Clinics of North America·S L Morgan
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B E Christopher Nordin
Nov 1, 1997·Plant Disease·T R GottwaldT D Riley
Sep 28, 2004·The American Journal of Clinical Nutrition·B E Christopher NordinMichael Horowitz
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·P K FarmerM S Nanes
Apr 24, 2003·The Annals of Pharmacotherapy·Samantha F EichnerErin M Timpe

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