PMID: 4293789Oct 1, 1967Paper

The responses of thalamic neurons to iontophoretically applied monoamines

The Journal of Physiology
J W Phillis, A K Tebecis

Abstract

1. The effects of noradrenaline (NA), adrenaline, dopamine (DA) 5-hydroxytryptamine (5-HT) and a number of related drugs were tested on the extracellularly recorded responses of neurones in the feline thalamus. Substances were applied iontophoretically and tested on synaptically, antidromically and chemically evoked neuronal activity.2. NA, adrenaline, isoprenaline and 5-HT had a variety of effects, depressing some cells, exciting others and not affecting the responses of a third group. DA depressed most of the cells tested; excitation was not observed with this compound.3. The magnitude of depressant actions and their duration varied considerably. The more sensitive cells responded to extremely small amounts of catecholamine or 5-HT and recovery often took several minutes. Recovery after DA was always rapid. Neurones in the dorsal thalamus were generally more susceptible to depression than those in the ventro-basal complex.4. Excitatory responses were most marked in the ventro-basal complex of the thalamus. Desensitization occurred if NA or adrenaline was applied repeatedly and this tachyphylaxis lasted for several minutes. After desensitization to the excitatory effects, some of these cells were depressed by catecholamines. T...Continue Reading

Citations

Dec 1, 1969·International Journal of Neuropharmacology·E S JohnsonD W Straughan
Dec 1, 1969·International Journal of Neuropharmacology·H E Brezenoff, D J Jenden
Jul 1, 1968·British Journal of Pharmacology and Chemotherapy·J W PhillisD H York
Dec 1, 1972·Comparative and General Pharmacology·R C FredericksonJ W Phillis
Aug 1, 1988·Brain Research Bulletin·E R Dennett, J I Hubbard
Aug 1, 1972·Electroencephalography and Clinical Neurophysiology·H J Spencer
Apr 15, 2005·Neurological Research·Kresimir Krnjević
Dec 7, 1973·Brain Research·A K Tebecis
Sep 1, 1968·Brain Research·J W Phillis, D H York
Nov 19, 1971·Nature·T W Stone
May 8, 1990·The Journal of Comparative Neurology·K N WestlundW D Willis
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·R K FreundM R Palmer
Jul 26, 2018·Frontiers in Neural Circuits·Simon N Jacob, Hendrikje Nienborg
Mar 1, 1968·British Journal of Pharmacology and Chemotherapy·I McCanceR A Westerman
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·P BevanE Szabadi
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger

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