The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine

Immunopharmacology
P F SmithM Halonen

Abstract

Rings of intrapulmonary bronchi isolated from rabbits producing anti-horseradish peroxidase IgE antibodies contracted when exposed to antigen. The contractile response had a lag period of about 1 min, reached a peak at 6 min and then subsided. Bronchi from rabbits with detectable levels of specific IgG (in addition to IgE) antibodies did not differ in response from those with undetectable specific IgG levels. Histamine also contracted rabbit intrapulmonary bronchi with an EC50 of 10 micro (SD 1.29). The response to antigen was completely inhibited with chlorpheniramine (30 microM). In contrast to intrapulmonary bronchi, responsiveness of mainstem bronchi to antigen was observed only occasionally, whereas histamine was equipotent on both mainstem and intrapulmonary bronchi. Thus, the amount of antigen-induced mediator release may be less in the mainstem bronchi. Acetyl glyceryl ether phosphorylcholine, in concentrations up to 10 microM, did not contract either mainstem or intrapulmonary bronchi. This study indicates that histamine is the major mediator of (and acetyl glyceryl ether phosphorylcholine does not significantly participate in) antigen-induced contraction of isolated bronchi from IgE-producing rabbits. The results prov...Continue Reading

References

Apr 1, 1978·Agents and Actions·N Chand, P Eyre
May 1, 1974·The Journal of Allergy and Clinical Immunology·P D JoinerF Hahn
Jan 1, 1984·International Journal of Immunopharmacology·M Halonen, M Kaliner
Jul 18, 1984·Biochemical and Biophysical Research Communications·R N PinckardG E Mott

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Citations

Oct 12, 2011·Experimental Brain Research·Hassan Rohbanfard, Luc Proteau
Aug 26, 2011·Annals of Medicine·John D CarterAlan P Hudson

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