The restoration of chronotropic competence in heart failure patients with normal ejection fraction (RESET) study: rationale and design.

Journal of Cardiac Failure
David A KassGuy E Alvarez

Abstract

Heart failure with preserved ejection fraction (HFpEF) is the predominant form of heart failure among the elderly and in women. However, there are few if any evidence-based therapeutic options for HFpEF. The chief complaint of HFpEF is reduced tolerance to physical exertion. Recent data revealed that 1 potential mechanism of exertional intolerance in HFpEF patients is inadequate chronotropic response. Although there is considerable evidence demonstrating the benefits of rate-adaptive pacing (RAP) provided from implantable cardiac devices in patients with an impaired chronotropic response, the effect of RAP in HFpEF is unknown. The Restoration of Chronotropic CompEtence in Heart Failure PatientS with Normal Ejection FracTion (RESET) study is a prospective, multicenter, double-blind, randomized with stratification, study assessing the effect of RAP on peak oxygen consumption and quality of life. RAP therapy will be evaluated in a crossover paired fashion for each patient within each study stratum. Study strata are based on patient beta-blocker usage at time of enrollment. The study is powered to assess the impact of pacing independently in both strata. The RESET study seeks to evaluate the potential benefit of RAP in patients wit...Continue Reading

References

Jan 1, 1992·Circulation Research·C P ChengW C Little
Aug 1, 1992·Pacing and Clinical Electrophysiology : PACE·H Mond, N Strathmore
Nov 1, 1986·Pacing and Clinical Electrophysiology : PACE·L J Kappenberger, L Herpers
Feb 1, 1989·Pacing and Clinical Electrophysiology : PACE·C P LauA J Camm
Apr 1, 1989·The American Journal of Cardiology·C P LauA J Camm
Dec 1, 1986·The Journal of Clinical Investigation·C T TingF C Yin
Jul 1, 1984·The American Journal of Cardiology·R D WiensH L Kennedy
Jun 1, 1984·Clinical Cardiology·Y RozenmanM S Gotsman
May 1, 1995·International Journal of Cardiology·A L Clark, A J Coats
Apr 1, 1996·Pacing and Clinical Electrophysiology : PACE·L FeiA J Camm
Jan 4, 2001·The New England Journal of Medicine·S K GandhiW C Little
Jan 5, 2002·The American Journal of Geriatric Cardiology·Alberto U Ferrari
Jan 31, 2002·Pacing and Clinical Electrophysiology : PACE·R A FreedmanB L Wilkoff
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Dalane W KitzmanKathryn P Stewart
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Jan 30, 2004·Annual Review of Medicine·William H Gaasch, Michael R Zile
Jan 22, 2005·Pacing and Clinical Electrophysiology : PACE·Ayten Erol-YilmazRaymond Tukkie
May 20, 2005·European Heart Journal·Karl SwedbergUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology
Aug 24, 2005·Progress in Cardiovascular Diseases·William C Little, Steffen Brucks
Oct 6, 2005·Circulation·Margaret M RedfieldDavid A Kass
Dec 20, 2005·Journal of the American College of Cardiology·Hung-Fat TseChu-Pak Lau
Jan 13, 2006·Archives of Internal Medicine·Lawrence LiaoJohn S Gottdiener
Feb 28, 2006·Journal of Cardiac Failure· Heart Failure Society Of America
Mar 30, 2006·Journal of Cardiopulmonary Rehabilitation·Peter H BrubakerDalane W Kitzman
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Francesca BursiVéronique L Roger
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 25, 2007·European Heart Journal·Christophe TribouilloyZiad Massy

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Citations

Dec 9, 2010·European Heart Journal·Barry A Borlaug, Walter J Paulus
Mar 9, 2011·Circulation·Peter H Brubaker, Dalane W Kitzman
Jul 1, 2014·Heart Failure Clinics·Jose Nativi-NicolauJames C Fang
Aug 12, 2014·Journal of Cardiac Failure·Nicholas E Houstis, Gregory D Lewis
Feb 10, 2012·The American Journal of the Medical Sciences·Michael N YoungDaniel J Lenihan
Nov 30, 2013·Cardiology Clinics·Lisa J Rose-JonesPatricia P Chang
Mar 20, 2012·La Revue de médecine interne·P-V EnnezatS Maréchaux
Sep 20, 2015·Clinical Therapeutics·Shane Nanayakkara, David M Kaye
Apr 8, 2010·Cardiovascular Therapeutics·Aaron M From, Barry A Borlaug
Oct 21, 2011·Clinical & Developmental Immunology·Eric D AbstonDeLisa Fairweather
Oct 1, 2014·Journal of Cardiac Failure·Freddy AbnousiPaul Heidenreich
May 4, 2017·Clinical Pharmacology and Therapeutics·S Nanayakkara, D M Kaye
Mar 26, 2015·Current Opinion in Cardiology·Sara Tannenbaum, Gabriel T Sayer
Mar 14, 2020·Circulation. Heart Failure·Satyam SarmaBenjamin D Levine
Aug 23, 2019·Der Internist·Johannes Petutschnigg, Frank Edelmann
Oct 26, 2018·Circulation. Heart Failure·Alwin ZweerinkCornelis P Allaart
Jun 7, 2015·Journal of Applied Physiology·Satyam Sarma, Benjamin D Levine

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