The RESTORE Randomized Controlled Trial: Impact of a Multidisciplinary Rehabilitative Program on Cardiorespiratory Fitness in Esophagogastric cancer Survivorship

Annals of Surgery
Linda M O'NeillJuliette Hussey

Abstract

The Rehabilitation Strategies in Esophagogastric cancer (RESTORE) randomized controlled trial evaluated the efficacy of a 12-week multidisciplinary program to increase the cardiorespiratory fitness and health-related quality of life (HRQOL) of esophagogastric cancer survivors. Patients following treatment for esophagogastric cancer are at risk of physical deconditioning, nutritional compromise, and sarcopenia. Accordingly, compelling rationale exists to target these impairments in recovery. Disease-free patients treated for esophagogastric cancer were randomized to either usual care or the 12-week RESTORE program (exercise training, dietary counseling, and multidisciplinary education). The primary outcome was cardiopulmonary exercise testing (VO2peak). Secondary outcomes included body composition (bioimpedance analysis), and HRQOL (EORTC-QLQ-C30). Outcomes were assessed at baseline (T0), postintervention (T1), and at 3-month follow-up (T2). Twenty-two participants were randomized to the control group [mean (standard deviation) age 64.14 (10.46) yr, body mass index 25.67 (4.83) kg/m, time postsurgery 33.68 (19.56) mo], and 21 to the intervention group [age 67.19(7.49) yr, body mass index 25.69(4.02) kg/m, time postsurgery 23.52(...Continue Reading

Associated Clinical Trials

References

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Citations

Jun 18, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Jarlath C BolgerWilliam B Robb
Apr 10, 2020·Current Osteoporosis Reports·Nicole KissRobin M Daly
Mar 30, 2020·Journal of Cancer Survivorship : Research and Practice·Linda O'NeillJuliette Hussey
Dec 12, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Shuhei MayanagiYuko Kitagawa
Jan 6, 2021·Cancers·Annemarie E BennettJuliette Hussey
Mar 12, 2021·Health & Social Care in the Community·Gráinne SheillEmer Guinan
Feb 4, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Junjie WangGuohao Wu
Jun 2, 2021·Critical Reviews in Oncology/hematology·Maximilian KoeppelJoachim Wiskemann
Jul 13, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Kazuaki MatsuiYuko Kitagawa
Aug 25, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Elja A E ReijneveldCindy Veenhof

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