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The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content

The Journal of Immunology : Official Journal of the American Association of Immunologists

May 1, 2013

Jennifer I C BenichouYoram Louzoun

Abstract

The Ab repertoire is not uniform. Some variable, diversity, and joining genes are used more frequently than others. Nonuniform usage can result from the rearrangement process, or from selection. To study how the Ab repertoire is selected, we analyzed one part of diversity generation tha...read more

Mentioned in this Paper

Gene Deletion Abnormality
IgA2
IgM2
Immunoglobulin Heavy Chain Subgroup VH-III
Immunoglobulin Isotypes
DNA Sequence Rearrangement
Deletion Mutation
Gene Amplification Technique
V(D)J Recombination
Chromosome Inversion
Paper Details
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The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content

The Journal of Immunology : Official Journal of the American Association of Immunologists

May 1, 2013

Jennifer I C BenichouYoram Louzoun

PMID: 23630353

DOI: 10.4049/jimmunol.1201929

Abstract

The Ab repertoire is not uniform. Some variable, diversity, and joining genes are used more frequently than others. Nonuniform usage can result from the rearrangement process, or from selection. To study how the Ab repertoire is selected, we analyzed one part of diversity generation tha...read more

Mentioned in this Paper

Gene Deletion Abnormality
IgA2
IgM2
Immunoglobulin Heavy Chain Subgroup VH-III
Immunoglobulin Isotypes
DNA Sequence Rearrangement
Deletion Mutation
Gene Amplification Technique
V(D)J Recombination
Chromosome Inversion

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