The restriction point and control of cell proliferation

Current Opinion in Cell Biology
M D Planas-Silva, R A Weinberg

Abstract

Research over the past two decades has defined a window of time in the early/mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals. Recent evidence indicates that this period ends with the phosphorylation of the retinoblastoma protein, enabling the cells to pass through the restriction point at the end of mid G1 phase and to commit to completing the remaining phases of the growth cycle.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P W RossowA B Pardee
Feb 1, 1990·Experimental Cell Research·M Lalande
Nov 3, 1989·Science·A B Pardee
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A B Pardee
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y Geng, R A Weinberg
May 1, 1995·Molecular and Cellular Biology·M OhtsuboM Pagano
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Jul 1, 1995·Molecular and Cellular Biology·D Resnitzky, S I Reed
Nov 18, 1994·Cell·C J Sherr
Dec 1, 1995·Current Opinion in Cell Biology·F R Cross
Dec 1, 1995·Current Opinion in Cell Biology·A ZetterbergK G Wiman
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·K OhtaniJ R Nevins
Mar 8, 1996·The Journal of Biological Chemistry·S MuthukkumarV M Rangnekar
Aug 23, 1996·The Journal of Biological Chemistry·J N LavoieJ Pouysségur
Aug 1, 1996·Molecular and Cellular Biology·D AgrawalW J Pledger
Sep 1, 1996·Molecular and Cellular Biology·A SchulzeB Henglein
Dec 1, 1996·Current Opinion in Cell Biology·J BartekJ Lukas
Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·N R WilckenR L Sutherland
Feb 7, 1997·Cell·A G PaulovichL H Hartwell
Jan 1, 1996·Critical Reviews in Oncogenesis·G DelSalM Pagano
Mar 1, 1997·Genes & Development·A C LloydH Land
May 9, 1997·The Journal of Biological Chemistry·T Zarkowska, S Mittnacht

❮ Previous
Next ❯

Citations

Apr 3, 2004·Trends in Molecular Medicine·Mark E Ewen, Justin Lamb
Jun 7, 2011·Molecular Oncology·Aygül Dereli-ÖzThanos D Halazonetis
May 30, 2001·Molecular and Cellular Endocrinology·N Takuwa, Y Takuwa
Jun 18, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·F BeierP LuValle
Jan 23, 1999·Current Opinion in Cell Biology·P D Adams, W G Kaelin
Jan 8, 1999·Mutation Research·M HengstschlägerE Hengstschläger-Ottnad
Jan 29, 2000·Mutation Research·C Cerni
Jul 20, 2007·Nature Reviews. Molecular Cell Biology·Hilary A Coller
Apr 12, 2000·European Journal of Biochemistry·L A StivalaE Prosperi
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrea K BryanScott R Manalis
Mar 23, 2000·The Journal of Experimental Medicine·R HalabanJ Germino
Jan 30, 2002·Antioxidants & Redox Signaling·S WisemanA Rietveld
Feb 13, 2001·Molecular Biology of the Cell·Z A Zimmerman, D R Kellogg
Sep 18, 2001·Journal of Virology·D ChattopadhyayM L Harter
Nov 5, 2002·Journal of Virology·Emanuela NorisSanto Landolfo
Nov 14, 2000·Molecular and Cellular Biology·T K BaguiW J Pledger
Jun 9, 2006·Cell Division·Floris Foijer, Hein Te Riele
Mar 8, 2014·Journal of Physiology and Biochemistry·Irving Omar Estévez-GarcíaEdgar Abarca-Rojano
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·R FerreiraD Trouche
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·F BeierP LuValle
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A Lees, R A Weinberg
Dec 3, 2014·Pharmacological Reports : PR·Shruti SetiaSankar N Sanyal
Mar 24, 2004·Seminars in Cell & Developmental Biology·Edward M Levine, Eric S Green
Mar 11, 1999·Current Opinion in Genetics & Development·M Polymenis, E V Schmidt
Jun 10, 2000·Molecular Biology of the Cell·X ZhangW J Pledger
Apr 19, 2015·Advanced Drug Delivery Reviews·Sang-Ging OngJoseph C Wu
Feb 27, 2001·FEBS Letters·S M Jones, A Kazlauskas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.