The Restrictome of Flaviviruses.

Virologica Sinica
Lionel Berthoux

Abstract

Flaviviruses are a genus of mostly arthropod-borne RNA viruses that cause a range of pathologies in humans. Basic knowledge on flaviviruses is rapidly expanding, partly due to their status as frequent emerging or re-emerging pathogens. Flaviviruses include the dengue, Zika, West Nile, tick-borne encephalitis and yellow fever viruses (DENV, ZIKV, WNV, TBEV and YFV, respectively). As is the case with other families of viruses, the success of productive infection of human cells by flaviviruses depends in part on the antiviral activity of a heterogeneous group of cellular antiviral proteins called restriction factors. Restriction factors are the effector proteins of the cell-autonomous innate response against viruses, an immune pathway that also includes virus sensors as well as intracellular and extracellular signal mediators such as type I interferons (IFN-I). In this review, I summarize recent progress toward the identification and characterization of flavivirus restriction factors. In particular, I focus on IFI6, Schlafen 11, FMRP, OAS-RNase L, RyDEN, members of the TRIM family of proteins (TRIM5α, TRIM19, TRIM56, TRIM69 and TRIM79α) and a new mechanism of action proposed for viperin. Recent and future studies on this topic wil...Continue Reading

References

May 2, 2001·The EMBO Journal·A ReymondA Ballabio
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·K C Chin, P Cresswell
Jun 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrey A PerelyginMargo A Brinton
Aug 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tomoji MashimoPhilippe Despres
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jorge L Muñoz-JordanAdolfo García-Sastre
Nov 18, 2004·Immunological Reviews·Sidney PestkaMark R Walter
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sara L SawyerHarmit S Malik
Aug 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karla J HelbigMichael R Beard
Jan 26, 2006·The Journal of Biological Chemistry·Kieran M Short, Timothy C Cox
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark A RivieccioCelia F Brosnan
Dec 7, 2007·PLoS Neglected Tropical Diseases·Joshua FinkMartin L Hibberd
Jan 18, 2008·Nature·Stuart J D NeilPaul D Bieniasz
Feb 6, 2008·The Journal of Cell Biology·Edward M CampbellThomas J Hope
Feb 12, 2008·Lancet·E A Gould, T Solomon
Oct 7, 2008·Nature Reviews. Immunology·Keiko OzatoHerbert C Morse
Mar 18, 2009·PloS One·Laetitia CarthagenaSébastien Nisole
Aug 22, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael S Diamond
Nov 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ella R Hinson, Peter Cresswell
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ren-Jye LinYi-Ling Lin
Jan 12, 2010·Current Opinion in Immunology·Courtney Wilkins, Michael Gale
Feb 24, 2010·FEBS Letters·Kaitlin S Duschene, Joan B Broderick
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Jun 23, 2010·Viral Immunology·Alison D AugustinePatricia M Repik
Nov 17, 2010·Nature Reviews. Microbiology·Maria G GuzmanRosanna W Peeling
Dec 3, 2010·Current Opinion in Immunology·Su-Yang LiuGenhong Cheng
Dec 15, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katherine A Fitzgerald

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Citations

Jun 4, 2020·Vaccines·Marie-France Martin, Sébastien Nisole
Sep 10, 2020·Expert Review of Clinical Immunology·Fatemeh Heidary, Reza Gharebaghi
Aug 25, 2020·Current Clinical Microbiology Reports·Maria I GiraldoRicardo Rajsbaum
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Cara J WestmarkYoshihiro Kawaoka

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Methods Mentioned

BETA
co-immunoprecipitation

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