The results of pacing trials for the prevention and termination of atrial tachyarrhythmias: is there any evidence of therapeutic breakthrough?

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Irina Savelieva, A John Camm

Abstract

Atrial fibrillation (AF) is now recognized as the most prevalent sustained cardiac arrhythmia and it is associated with considerable mortality and morbidity. The demand for effective therapeutic strategies for AF has always been high and is anticipated to further increase. Anticoagulation and pharmacologic antiarrhythmic therapy or radiofrequency catheter ablation remain the mainstay of treatment for AF. Among the wide range of nonpharmacologic options which are presently being investigated, only ablation in or around the pulmonary veins and the surgical maze procedure have been shown to accomplish the aim of the curative treatment of the arrhythmia. Preventative atrial pacing and antitachycardia pacing may offer an attractive alternative option for the management of AF by either eliminating the triggers and/or by modifying the substrate of the arrhythmia. The results of several recent trials have shown a significant increase in the time to first AF recurrence, a decrease in atrial conduction time, and a trend towards reduction in AF burden, suggesting that atrial pacing may prevent AF due to improved synchronization of atrial depolarization. The recognition of potential triggers of AF, such as atrial premature complexes, short...Continue Reading

Citations

Jan 22, 2005·Annual Review of Medicine·Ashish AgarwalMichael Ezekowitz
Dec 16, 2006·Pacing and Clinical Electrophysiology : PACE·Renato P RicciMassimo Santini
Apr 30, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Renato Pietro RicciUNKNOWN DATAS study Investigators
Aug 4, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Emmanuel N SimantirakisPanos E Vardas
Jan 20, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Massimo SantiniTiziana De Santo
Mar 21, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Massimo Santini, Renato P Ricci
Aug 13, 2004·Pacing and Clinical Electrophysiology : PACE·I Eli Ovsyshcher, S Serge Barold
Apr 3, 2008·Clinical Cardiology·Irina Savelieva, John Camm
Feb 23, 2018·Journal of Cardiovascular Medicine·Matteo ZiacchiUNKNOWN Italian Association of Arrhythmology and Cardiac Pacing (AIAC)
May 23, 2009·Journal of Cardiovascular Electrophysiology·Chu-Pak LauUNKNOWN SAFE Study Steering Committee for SAFE Study Group
Mar 24, 2005·Progress in Cardiovascular Nursing·Carol Chen-Scarabelli
Mar 18, 2015·Nature Reviews. Cardiology·Giuseppe Boriani, Luigi Padeletti

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