The resurgence of the norovirus GII.4 variant associated with sporadic gastroenteritis in the post-GII.17 period in South China, 2015 to 2017

BMC Infectious Diseases
Liang XueQingping Wu

Abstract

Human norovirus is regarded as the leading cause of nonbacterial acute diarrhea in developing and developed countries. Among all genotypes, GII.4 has been the predominant genotype, but in East Asia, it was replaced by the GII.17 in 2014/2015. However, after the prevalence of new GII.17 variant in South China, a sharply increase in the number of norovirus infections associated with sporadic acute diarrhea was detected. In this study, we would investigate the prevalence and genetic diversity of noroviruses in the sporadic acute gastroenteritis cases in the post-GII.17 period in South China. Norovirus was screened from 217 patients with sporadic acute gastroenteritis from August 2015 to October 2017 by reverse transcription-polymerase chain reaction. Then, two regions including the partial RNA polymerase and the capsid gene of positive samples were amplified and sequenced. Phylogenetic analyses were performed to determine norovirus genotypes. Complete VP1 sequences of GII.4 strains detected in this study were also amplified and subjected into evolutionary tracing analyses. A total of 43 (19.82%) norovirus samples were confirmed from 217 stool specimens, and it was found that GII.4 resurged as the new predominant variant, accountin...Continue Reading

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Citations

Oct 18, 2020·Viruses·Sandra NiendorfSonja Jacobsen
Jan 6, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Takako UtsumiIkuo Shoji
Apr 24, 2021·Frontiers in Microbiology·Yueting ZuoQingping Wu
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jasmin DülferCharlotte Uetrecht
Dec 3, 2021·Indian Journal of Medical Microbiology·K NagamaniSunitha Pakalapaty

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Datasets Mentioned

BETA
MH469166-MH469208

Methods Mentioned

BETA
Genotyping

Software Mentioned

BioEdit® Sequence Alignment Editor
ClustalX
MEGA
Molecular Evolutionary Genetics Analysis ( MEGA )

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