The RET receptor is linked to stress response pathways

Cancer Research
Shirley M Myers, L M Mulligan

Abstract

RET is a transmembrane receptor required for the development of neuroendocrine and urogenital cell types. Activation of RET has roles in cell growth, migration, or differentiation, yet little is known about the gene expression patterns through which these processes are mediated. We have generated cell lines stably expressing either the RET9 or RET51 protein isoforms and have used these to investigate RET-mediated gene expression patterns by cDNA microarray analyses. As seen for many oncogenes, we identified altered expression of genes associated generally with cell-cell or cell-substrate interactions and up-regulation of tumor-specific transcripts. We also saw increased expression of transcripts normally associated with neural crest or other RET-expressing cell types, suggesting these genes may lie downstream of RET activation in development. The most striking pattern of expression was up-regulation of stress response genes. We showed that RET expression significantly up-regulated the genes for heat shock protein (HSP) 70 family members, HSPA1A, HSPA1B, and HSPA1L. Other members of several HSP families and HSP70-interacting molecules that were associated with stress response protein complexes involved in protein maturation were...Continue Reading

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Citations

May 3, 2005·Nature Reviews. Cancer·Stephen J Marx
Aug 10, 2012·Molecular Biology of the Cell·Douglas S RichardsonLois M Mulligan
May 6, 2010·Human Molecular Genetics·Daniela FuscoGiovanni Romeo
Jun 18, 2009·Blood·Megan S LimKojo S J Elenitoba-Johnson
Feb 20, 2009·Genes, Chromosomes & Cancer·Jessica G HickeyLois M Mulligan
Jul 28, 2012·Human Mutation·Brandy D HyndmanLois M Mulligan
Jun 29, 2005·Cytokine & Growth Factor Reviews·Elena ArighiHannu Sariola
Oct 28, 2014·Oncogene·M Y Sherman, V L Gabai
Jul 12, 2017·Zygote : the Biology of Gametes and Early Embryos·Mehdi Vafaye VallehPoul Hyttel
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Rodrigo A ToledoSergio P A Toledo
Nov 17, 2006·Cancer Research·Taranjit S GujralLois M Mulligan
Jul 18, 2021·Molecular and Cellular Neurosciences·Joanne E KearonM G Blennerhassett

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