The retrograde transport of horseradish peroxidase from the developing limb of the chick embryo.

Brain Research
R W Oppenheim, M B Heaton

Abstract

Chick embryos ranging in age from 4.0 to 18 days of incubation and 1-2-day-old hatchlings received injections of HRP solutions directly into the leg musculature. After survival periods of from 5 to 25 h motoneurons and cells in the spinal sensory ganglia were found to be stained with the HRP reaction product. It was found that the first appearance of a positive HRP reaction coincided with the time when nerve processes are first detected in the limb-bud by silver techniques (i.e. at 4.5 days of incubation). Only neurons with processes in the region of injection showed a positive reaction. The demonstration of a retrograde transport mechanism in neurons and axons which are still undergoing growth and differentiation provides a possible mechanism for the peripheral regulation of certain features of CNS neurogenesis. The application of this technique during development may also allow one to map neuroanatomical pathways during their formation.

References

Apr 15, 1975·The Journal of Comparative Neurology·V Hamburger
Jul 1, 1975·The Journal of Physiology·L Landmesser, D G Morris
Jun 18, 1971·Brain Research·K Kristensson, Y Olsson
Sep 1, 1974·The Journal of Physiology·L Landmesser, G Pilar
Sep 1, 1974·The Journal of Physiology·M R Bennett, A G Pettigrew
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G GiacobiniJ P Changeux
Feb 1, 1973·The Journal of Physiology·J BagustR A Westerman
Feb 1, 1973·The Journal of Comparative Neurology·L A Rogers, W M Cowan
Jun 30, 1972·Science·J H LaVail, M M LaVail
Jun 22, 1972·Brain Research·M C Prestige, M A Wilson
Nov 1, 1969·Journal of Morphology·A E Flanagan
Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·H Hirano
Jun 1, 1968·The Journal of Comparative Neurology·W M Cowan, E Wenger
Nov 1, 1968·Paraplegia·R R Hughes
May 1, 1958·The American Journal of Anatomy·V HAMBURGER

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Citations

Jan 1, 1985·Neir̆ofiziologiia = Neurophysiology·A A Veluman
Nov 21, 1995·Brain Research. Developmental Brain Research·M B HeatonD W Walker
Nov 1, 1978·Brain Research Bulletin·M B Heaton, M E Kosier
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CatsicasM C Wilson
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M HollydayJ M Farris
Jul 23, 1984·Brain Research·Z Seltzer, M Devor
Jan 1, 1997·Molecular and Cellular Neurosciences·J A CampagnaJ L Bixby
Nov 24, 1999·FEBS Letters·J C Perron, J L Bixby
Nov 1, 1980·The Journal of Comparative Neurology·M Hollyday
Jan 1, 1987·Journal of Neuroscience Research·M B Heaton, H Kemperman
Aug 20, 1983·The Journal of Comparative Neurology·M D Barnes, K E Alley
Apr 1, 1980·The Journal of Comparative Neurology·D M Noden
Oct 1, 1980·The Journal of Comparative Neurology·I W Chu-Wang, R W Oppenheim
Jan 20, 1981·The Journal of Comparative Neurology·G O Ivy, H P Killackey
Feb 8, 1985·The Journal of Comparative Neurology·G H Gross

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