The reuniens and rhomboid nuclei are necessary for contextual fear memory persistence in rats

Brain Structure & Function
Etienne QuetAline Stéphan

Abstract

Memory persistence refers to the process by which a temporary, labile memory is transformed into a stable and long-lasting state. This process involves a reorganization of brain networks at systems level, which requires functional interactions between the hippocampus (HP) and medial prefrontal cortex (mPFC). The reuniens (Re) and rhomboid (Rh) nuclei of the ventral midline thalamus are bidirectionally connected with both regions, and we previously demonstrated their crucial role in spatial memory persistence. We now investigated, in male rats, whether specific manipulations of ReRh activity also affected contextual and cued fear memory persistence. We showed that the permanent ReRh lesion impaired remote, but not recent contextual fear memory. Tone-cued recent and remote fear memory were spared by the lesion. In intact rats, acute chemogenetic ReRh inhibition conducted before recall of either recent or remote contextual fear memories produced no effect, indicating that the ReRh nuclei are not required for retrieval of such memories. This was also suggested by a functional cellular imaging approach, as retrieval did not alter c-fos expression in the ReRh. Collectively, these data are compatible with a role for the ReRh in 'off-l...Continue Reading

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Citations

Sep 22, 2020·Brain and Neuroscience Advances·Etienne QuetAline Stéphan
Nov 27, 2020·Neurobiology of Learning and Memory·Fernanda Troyner, Leandro Jose Bertoglio
Nov 28, 2020·Neuroscience and Biobehavioral Reviews·M WolffA Groh
Feb 26, 2021·Neuroscience and Biobehavioral Reviews·Maëva FerrarisPascale P Quilichini
Mar 27, 2021·Neuroscience and Biobehavioral Reviews·Jean-Christophe CasselAnne Pereira de Vasconcelos
Jul 5, 2021·Neuroscience and Biobehavioral Reviews·Amy L Griffin

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