PMID: 37297May 1, 1979

The reversal by pyridostigmine of neuromuscular block produced by soman

The Journal of Pharmacy and Pharmacology
M C FrenchP D White


The effect of pyridostigmine on neuromuscular block produced by soman was studied in the isolated phrenic nerve-diaphragm preparation. In the rat, soman produced an irreversible reduction in tetanic tension and functional acetylcholinesterase (AChE) activity. Pretreatment with pyridostigmine before exposure of the diaphragm to soman, followed by removal of the anticholinesterase from the organ bath, produced a return of tetanic tension and an increase of 5% in functional AChE activity. Similar results were obtained in the guinea-pig. The changes in synaptic AChE activity were verified pharmacologically by showing a decrease in the blocking activity of acetylcholine in preparations pretreated with pyridostigmine in comparison to those given soman alone following removal of the anti-cholinesterase. The blocking dose of carbachol did not change in these two groups indicating that desensitization was not a component of the protective action. A comparison was also made of the results obtained by measuring inhibition of AChE in situ with those obtained from muscle homogenates. The implications of these results are discussed.


Jul 1, 1978·The Journal of Pharmacy and Pharmacology·P Dirnhuber, D M Green
Jan 1, 1978·Toxicology and Applied Pharmacology·J J GordonM P Maidment
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·J Knoll
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Feb 1, 1966·British Journal of Pharmacology and Chemotherapy·R D BirtleyA Wilson
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Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING


Jun 12, 1999·Muscle & Nerve·R Drake-Baumann, F J Seil
Feb 1, 1992·Journal of Applied Toxicology : JAT·M AdlerE X Albuquerque
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·D W BlickS L Hartgraves
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·David S JanowskyDavid H Overstreet
Oct 28, 1998·Journal of Physiology, Paris·R Drake-BaumannP S Spencer
Aug 4, 2009·Toxicology and Applied Pharmacology·Corey J HilmasPatrick T Williams
Nov 1, 1980·Journal of Periodontal Research·J L EbersoleD J Smith
Aug 2, 2005·Pharmacology, Biochemistry, and Behavior·David S JanowskyDavid H Overstreet
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Acetylcholine Sulfate (1: 1)
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