PMID: 37297May 1, 1979

The reversal by pyridostigmine of neuromuscular block produced by soman

The Journal of Pharmacy and Pharmacology
M C FrenchP D White

Abstract

The effect of pyridostigmine on neuromuscular block produced by soman was studied in the isolated phrenic nerve-diaphragm preparation. In the rat, soman produced an irreversible reduction in tetanic tension and functional acetylcholinesterase (AChE) activity. Pretreatment with pyridostigmine before exposure of the diaphragm to soman, followed by removal of the anticholinesterase from the organ bath, produced a return of tetanic tension and an increase of 5% in functional AChE activity. Similar results were obtained in the guinea-pig. The changes in synaptic AChE activity were verified pharmacologically by showing a decrease in the blocking activity of acetylcholine in preparations pretreated with pyridostigmine in comparison to those given soman alone following removal of the anti-cholinesterase. The blocking dose of carbachol did not change in these two groups indicating that desensitization was not a component of the protective action. A comparison was also made of the results obtained by measuring inhibition of AChE in situ with those obtained from muscle homogenates. The implications of these results are discussed.

References

Jul 1, 1978·The Journal of Pharmacy and Pharmacology·P Dirnhuber, D M Green
Jan 1, 1978·Toxicology and Applied Pharmacology·J J GordonM P Maidment
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·J Knoll
Sep 1, 1971·Biochemical Pharmacology·T W MittagR M Hehir
Feb 1, 1966·British Journal of Pharmacology and Chemotherapy·R D BirtleyA Wilson
Sep 1, 1953·British Journal of Pharmacology and Chemotherapy·J M BARNES, J I DUFF
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING

Citations

Jun 12, 1999·Muscle & Nerve·R Drake-Baumann, F J Seil
Feb 1, 1992·Journal of Applied Toxicology : JAT·M AdlerE X Albuquerque
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·D W BlickS L Hartgraves
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·David S JanowskyDavid H Overstreet
Oct 28, 1998·Journal of Physiology, Paris·R Drake-BaumannP S Spencer
Aug 4, 2009·Toxicology and Applied Pharmacology·Corey J HilmasPatrick T Williams
Nov 1, 1980·Journal of Periodontal Research·J L EbersoleD J Smith
Aug 2, 2005·Pharmacology, Biochemistry, and Behavior·David S JanowskyDavid H Overstreet
Feb 1, 1990·Human Factors·V J GawronJ F Ball

Related Concepts

Acetylcholine Sulfate (1: 1)
Acetylthiocholinesterase
Carboptic
Inotropism
Nerve-Muscle Preparation
Organopyrophosphorus Compounds
Structure of Phrenic Nerve
Pyridostigmine
Soman

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.