PMID: 589562Dec 1, 1977

The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45,X/46,Xr(X)) young woman treated with Clomid

Cancer
M MoukhtarS L Romney

Abstract

A 22 year-old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years.

References

Jan 15, 1976·American Journal of Obstetrics and Gynecology·G P Wood, R C Boronow
Aug 1, 1972·Annals of Internal Medicine·C W Heath
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B ForkmanG Rannevik

Citations

Jan 10, 2002·Biochemical and Biophysical Research Communications·A El-ObeidMonica Nistér
Jun 1, 1994·British Journal of Obstetrics and Gynaecology·C H LaiY K Soong
May 1, 1982·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A SmithG D Dulk
Feb 1, 1982·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A G OstorD W Fortune
Sep 24, 2005·The Oncologist·Mario M Leitao, Dennis S Chi
Jun 1, 1978·Journal of Medical Genetics·L Y HsuK Hirschhorn

Related Concepts

Carcinoma, Cribriform
Autosome Abnormalities
Serophene
Simple Endometrial Hyperplasia
Mosaicism
Ovarian Stimulation
Sex Chromosomes
Uterine Cancer
X Chromosome

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