PMID: 589562Dec 1, 1977

The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45,X/46,Xr(X)) young woman treated with Clomid

M MoukhtarS L Romney


A 22 year-old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years.


Jan 15, 1976·American Journal of Obstetrics and Gynecology·G P Wood, R C Boronow
Aug 1, 1972·Annals of Internal Medicine·C W Heath
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B ForkmanG Rannevik


Jan 10, 2002·Biochemical and Biophysical Research Communications·A El-ObeidMonica Nistér
Jun 1, 1994·British Journal of Obstetrics and Gynaecology·C H LaiY K Soong
May 1, 1982·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A SmithG D Dulk
Feb 1, 1982·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A G OstorD W Fortune
Sep 24, 2005·The Oncologist·Mario M Leitao, Dennis S Chi
Jun 1, 1978·Journal of Medical Genetics·L Y HsuK Hirschhorn

Related Concepts

Carcinoma, Cribriform
Autosome Abnormalities
Simple Endometrial Hyperplasia
Ovarian Stimulation
Sex Chromosomes
Uterine Cancer
X Chromosome

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.