The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice.

European Journal of Pharmacology
Alexander T NguyenKabirullah Lutfy

Abstract

We have previously shown that β-endorphin plays a functional role in the rewarding effect of acute cocaine. Considering that β-endorphin has high affinity for the μ opioid receptor, we determined the role of this receptor in the rewarding action of acute cocaine. For comparison, we assessed the role of the μ opioid receptor in the rewarding effect of acute morphine. We also examined the effect of intracerebroventricular (i.c.v.) administration of β-funaltrexamine (β-FNA), an irreversible μ opioid receptor antagonist, on the rewarding action of acute cocaine as well as that of morphine. Using the conditioned place preference (CPP) paradigm as an animal model of reward, we first assessed the rewarding action of cocaine in mice lacking β-endorphin or the μ opioid receptor and their respective wild-type littermates/controls. Mice were tested for preconditioning place preference on day 1, conditioned once daily with saline/cocaine (30mg/kg, i.p.) or cocaine/saline on days 2 and 3, and then tested for postconditioning place preference on day 4. We next studied the rewarding action of acute morphine in μ knockout mice and their wild-type controls. The CPP was induced by single alternate-day saline/morphine (10mg/kg, s.c.) or morphine/...Continue Reading

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Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Jun 27, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yahav DikshteinGal Yadid
Jan 18, 2016·Journal of Photochemistry and Photobiology. B, Biology·Anna JussilaErna Snellman
Jun 21, 2014·Cell·Gillian L FellDavid E Fisher
Feb 24, 2016·The Journal of Pharmacology and Experimental Therapeutics·Sarah A SushchykJia Bei Wang
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Dec 7, 2018·Psychopharmacology·Fair M VassolerElizabeth M Byrnes
Jan 6, 2021·International Journal of Molecular Sciences·Alexander PilozziXudong Huang

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