The Rgr oncogene induces tumorigenesis in transgenic mice

Cancer Research
M JiménezA Pellicer

Abstract

To study the oncogenic potential of Rgr in vivo, we have generated several transgenic Rgr mouse lines, which express the oncogene under the control of different promoters. These studies revealed that Rgr expression leads to the generation of various pathological alterations, including fibrosarcomas, when its transgenic expression is restricted to nonlymphoid tissues. Moreover, the overall incidence and latency of fibrosarcomas were substantially increased and shortened, respectively, in a p15INK4b-defective background. More importantly, we also have demonstrated that Rgr expression in thymocytes of transgenic mice induces severe alterations in the development of the thymocytes, which eventually lead to a high incidence of thymic lymphomas. This study demonstrates that oncogenic Rgr can induce expression of p15INK4b and, more importantly, that both Rgr and p15INK4b cooperate in the malignant phenotype in vivo. These findings provide new insights into the tumorigenic role of Rgr as a potent oncogene and show that p15INK4b can act as a tumor suppressor gene.

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Citations

Sep 8, 2012·Cancer Gene Therapy·R SuzmeA Pellicer
Jan 26, 2008·Nature Reviews. Cancer·Brian O Bodemann, Michael A White
Jan 10, 2012·Carcinogenesis·Kwame Osei-SarfoAngel Pellicer
May 1, 2012·Small GTPases·David F Kashatus, Christopher M Counter
Mar 22, 2015·Journal of Biochemistry·Ryutaro Shirakawa, Hisanori Horiuchi
Jan 21, 2006·Cancer Research·Naoki MoritoSatoru Takahashi

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