PMID: 11904600Mar 21, 2002Paper

The rhesus macaque as an animal model for pelvic organ prolapse

American Journal of Obstetrics and Gynecology
Lesley N OttoRobert M Brenner

Abstract

The purpose of this study was to characterize the pelvic floor of the rhesus macaque as an experimental model for human pelvic organ prolapse and to initiate an evaluation of the effects of estradiol and progesterone on the rhesus paravaginal attachment. Histologic specimens were prepared from the paravaginal attachment of 13 oophorectomized rhesus macaques. Three animals were treated with estradiol; 6 animals were treated with estradiol and progesterone, and 4 animals were untreated (hormone deprived). Immunocytochemistry was used to localize steroid receptors in the paravaginal attachment. Spontaneous pelvic organ prolapse was observed in rhesus macaques. The paravaginal attachment is comprised of dense collagen and elastic fibers that infiltrate the levator ani muscle. The fibroblasts of this attachment are estrogen and progesterone receptor positive, and the receptors are hormone responsive. The rhesus macaque has pelvic floor anatomy that is similar to women and makes an excellent experimental model for the study of prolapse. The rhesus paravaginal attachment is ligamentous and hormone sensitive. Its fibroblast activity may be modified by estrogen treatment in a manner similar to that reported in human pelvic connective ti...Continue Reading

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Citations

Feb 14, 2016·International Urogynecology Journal·Katrina M KnightSteven D Abramowitch
Jan 17, 2012·Urology·Chrystèle RubodBoris Gabriel
Mar 17, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Steven D AbramowitchPamela A Moalli
Aug 17, 2006·BJU International·Michael AlboFirouz Daneshgari
Jan 27, 2005·American Journal of Obstetrics and Gynecology·Pamela A MoalliSavio L-Y Woo
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Wenjun ZongPamela A Moalli
May 20, 2005·American Journal of Obstetrics and Gynecology·Amanda L ClarkRobert M Brenner
Jan 22, 2015·Current Urology Reports·Jamie Chao, Toby C Chai
Jun 2, 2016·World Journal of Stem Cells·Stuart J Emmerson, Caroline E Gargett
Aug 5, 2004·Obstetrics and Gynecology·W Thomas GregoryAmanda L Clark
May 24, 2011·Female Pelvic Medicine & Reconstructive Surgery·Wenjun ZongPamela A Moalli
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ov D SlaydenRobert M Brenner
Jan 18, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Megan Schimpf, Paul Tulikangas
Jun 19, 2012·Expert Review of Obstetrics & Gynecology·Bruna M CouriMargot S Damaser
Jun 12, 2014·International Urogynecology Journal·Marianna AlperinRichard L Lieber
Mar 13, 2017·International Urogynecology Journal·Amanda M StewartMarianna Alperin
Dec 3, 2016·International Urogynecology Journal·Natharnia YoungCaroline E Gargett
Apr 23, 2019·Current Opinion in Urology·Katerina MackovaJan Deprest
Jan 24, 2021·International Urogynecology Journal·Marina Gabriela M C Mori da CunhaJan Deprest
Jul 30, 2021·Laboratory Animals·Gessiane Pereira da SilvaFrederico Ozanan Barros Monteiro

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