The Rhizobium leguminosarum regulator IrrA affects the transcription of a wide range of genes in response to Fe availability.

Molecular Genetics and Genomics : MGG
J D ToddA W Johnston

Abstract

We show that an unusual transcriptional regulator, called IrrA, regulates many genes in the symbiotic N2-fixing bacterium Rhizobium leguminosarum in response to iron availability. Several operons in R. leguminosarum are expressed at lower levels in cells grown in Fe-depleted compared to Fe-replete medium. These include hemA1, which encodes the haem biosynthesis enzyme amino-levulinic acid synthase; sufS2BCDS1XA, which specify enzymes for FeS cluster synthesis; rirA, a global, Fe-responsive transcriptional repressor; RL0400, which likely encodes an unusual FeS cluster scaffold; and the possible ferri-siderophore ABC transporter rrp1. Reduced expression in Fe-depleted medium was effected by IrrA, a member of the Fur super-family, which in Bradyrhizobium, the symbiont of soybeans, and in the mammalian pathogen Brucella, is unstable in Fe-replete conditions, due to an interaction with haem. The R. leguminosarum IrrA likely interacts with ICE (iron-control element) motifs, conserved sequences near the promoters of its target genes. The rirA, sufS2BCDS1XA and rrp1 genes are also known to be regulated by RirA, which represses their expression in Fe-replete medium. We present a possible model for iron-responsive gene regulation in Rhiz...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D H Figurski, D R Helinski
Sep 1, 1974·Journal of General Microbiology·J E Beringer
Jan 1, 1981·Journal of Molecular Evolution·J Felsenstein
Jul 1, 1995·Journal of Bacteriology·K M Page, M L Guerinot
Mar 1, 1994·Journal of Bacteriology·K M PageM L Guerinot
Aug 15, 1998·The Journal of Biological Chemistry·I HamzaM R O'Brian
Jan 19, 2000·Nucleic Acids Research·M S GelfandA A Mironov
May 20, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·J N AgarM K Johnson
Sep 5, 2001·Molecular Microbiology·A NienaberH M Fischer
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·C J SchwartzP J Kiley
Dec 26, 2001·Nucleic Acids Research·Alex BatemanErik L L Sonnhammer
Jan 29, 2002·Nucleic Acids Research·E M PaninaM S Gelfand
Dec 14, 2002·Microbiology·Jonathan D ToddAndrew W B Johnston
Feb 1, 2003·Archives of Microbiology·Kathryn A DurhamGeorge S Bullerjahn
Jun 28, 2003·FEMS Microbiology Reviews·Simon C AndrewsFrancisco Rodríguez-Quiñones
Oct 18, 2003·Journal of Bacteriology·Mayuree Fuangthong, John D Helmann
Apr 23, 2004·Molecular Microbiology·F Wayne OuttenGisela Storz
Jun 25, 2004·Nucleic Acids Research·Scott McGinnis, Thomas L Madden
Jul 9, 2004·Applied and Environmental Microbiology·Raúl PlateroElena Fabiano
Oct 19, 2004·Annual Review of Microbiology·Susan Gottesman
Nov 13, 2004·Genome Biology·Dmitry A RodionovMikhail S Gelfand
Dec 21, 2004·Nucleic Acids Research·Dennis A BensonDavid L Wheeler
Oct 6, 2005·Applied and Environmental Microbiology·Tzu-Chiao ChaoStefan Weidner
Oct 7, 2005·Microbiology·Marcela MartínezMarta Almirón

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Citations

Oct 14, 2006·Molecular Genetics and Genomics : MGG·Jianhua YangMark R O'brian
Mar 18, 2010·The Journal of Biological Chemistry·Chloe SingletonNick E Le Brun
Jun 25, 2010·The Journal of Biological Chemistry·Thomas H Hohle, Mark R O'Brian
Apr 17, 2012·Journal of Bacteriology·Rosalba Escamilla-Hernandez, Mark R O'Brian
Jan 27, 2009·Journal of Bacteriology·Patchara Ngok-NgamSkorn Mongkolsuk
Dec 19, 2006·PLoS Computational Biology·Dmitry A RodionovAndrew W B Johnston
Mar 5, 2013·Annual Review of Plant Biology·Michael Udvardi, Philip S Poole
Feb 21, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew W B JohnstonDmitry A Rodionov
Dec 19, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sandra K SmallMark R O'Brian
Jul 22, 2015·Annual Review of Microbiology·Mark R O'Brian
Nov 10, 2007·Environmental Microbiology·Timothy M CarltonClive W Ronson
Jun 16, 2006·FEMS Microbiology Reviews·Gesine RudolphHans-Martin Fischer
Jul 24, 2012·FEMS Microbiology Letters·Sakkarin BhubhanilSkorn Mongkolsuk
Jun 13, 2017·Metallomics : Integrated Biometal Science·Hualiang Pi, John D Helmann
Apr 6, 2018·Chemical Science·Ma Teresa Pellicer MartinezNick E Le Brun
Nov 19, 2014·Journal of Bacteriology·Semen A Leyn, Dmitry A Rodionov
Feb 9, 2019·Metallomics : Integrated Biometal Science·Isidro AbreuDaniel Raimunda
Sep 19, 2019·ELife·Ma Teresa Pellicer MartinezNick E Le Brun
May 14, 2011·Metallomics : Integrated Biometal Science·Pierre CornelisTiffany Vinckx
Feb 11, 2020·Canadian Journal of Microbiology·Huan ZhangChuangfu Chen
Oct 14, 2020·The Journal of Biological Chemistry·Justin M BradleyNick E Le Brun
Jan 18, 2021·The Journal of Biological Chemistry·Justin M BradleyNick E Le Brun

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