PMID: 9427843Jan 15, 1998Paper

The ribosomal elongation cycle and the movement of tRNAs across the ribosome

Progress in Nucleic Acid Research and Molecular Biology
K H NierhausD I Svergun

Abstract

Ribosome research has reached an exciting state, where two lines of experimental research have considerably improved our understanding of the ribosomal functions. On one hand, functional analysis has elucidated principles of both the decoding process and the tRNA movement on the ribosome during translocation. Experimental data leading to current competing models of the ribosomal elongation cycle can be reconciled by a new model, the alpha-epsilon model, according to which both tRNAs are tightly bound to a movable ribosomal domain. This alpha-epsilon domain carries the tRNA2.mRNA complex from the A and P sites to the P and E sites in the course of translocation maintaining the binding of both tRNAs. On the other hand, the location of tRNAs within the elongating ribosome can be directly determined for the first time by neutron scattering and electron microscopy. Both lines of evidence complement each other and define a frame for the first experimentally sound functional model of the elongating ribosome.

Citations

Oct 24, 2002·Clinical Orthopaedics and Related Research·Gustavo A NaderKaryn A Esser
Jul 31, 1999·The Journal of Biological Chemistry·J M DomínguezJ J Martín
Jul 17, 1998·Current Opinion in Structural Biology·S A Woodson, N B Leontis

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