The right place of interleukin-1 inhibitors in the treatment of Behçet's syndrome: a systematic review

Rheumatology International
Alessandra BettiolGiacomo Emmi

Abstract

Behçet's syndrome (BS) is a chronic (auto)-inflammatory disorder characterized by different clusters of symptoms, including mucocutaneous and ocular involvements. Interleukin-1 inhibitors anakinra (ANA), canakinumab (CAN), and gevokizumab (GEV) represent a promising therapeutic alternative in BS. To date, evidence on the use of ANA, CAN, and GEV is mainly based on small isolated studies or case series, and the real place of anti-IL1 agents in the treatment of BS is still unclear. We performed a systematic review of current evidence on the efficacy and safety of anti-IL1 agents in BS. The PubMed search yielded a total of 398 references, from which we retrieved 24 studies for inclusion (4 clinical trials, 6 observational studies, 14 case reports, case series or letters to the editor). Four studies evaluated the overall efficacy of IL-1 inhibitors, 15 studies focused on the specific efficacy of ANA, whereas efficacy of CAN and GEV was evaluated in 8 and 3 studies, respectively. Both ANA and CAN were associated with good control of mucocutaneous and ocular manifestations. ANA resulted effective also for osteoarticular manifestations. GEV was studied only for ocular manifestations, but gave contrasting results. Discordant evidence s...Continue Reading

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Sep 6, 2019·Current Rheumatology Reports·Gabriela M Espinoza, Jessica L Liu
Apr 30, 2020·Rheumatology·Omer Karadag, Ertugrul Cagri Bolek
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Aug 6, 2021·Laryngo- rhino- otologie·Ulrich KisserAlexander Glien

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