The right ventricle and pulmonary hypertension

Heart Failure Reviews
Mariëlle C van de VeerdonkNorbert F Voelkel

Abstract

In patients with pulmonary hypertension (PH), the primary cause of death is right ventricular (RV) failure. Improvement in RV function is therefore one of the most important treatment goals. In order to be able to reverse RV dysfunction and also prevent RV failure, a detailed understanding of the pathobiology of RV failure and the underlying mechanisms concerning the transition from a pressure-overloaded adapted right ventricle to a dilated and failing right ventricle is required. Here, we propose that insufficient RV contractility, myocardial fibrosis, capillary rarefaction, and a disturbed metabolism are important features of a failing right ventricle. Furthermore, an overview is provided about the potential direct RV effects of PH-targeted therapies and the effects of RV-directed medical treatments.

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Citations

Mar 31, 2017·The International Journal of Cardiovascular Imaging·Christine L JellisDeborah Kwon
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Aug 28, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Ethan D KwanDaniela Valdez-Jasso
Oct 16, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Bi-Xi ChenMin-Fu Yang

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